Impact of microparticles in cancer progression

Blood platelets are the principal source of cells known to shed small extracellular vesicles which package biologically active molecules. We have recently identified a new type of these vesicles (called microparticles/MPs) that contain mitochondria, which represent the energy producing motors for living cells. We have also discovered that MPs preferentially bind and internalize into leukemia […]

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Impact of microparticles in cancer progression – Year two

Blood platelets are the principal source of cells known to shed small extracellular vesicles which package biologically active molecules. We have recently identified a new type of these vesicles (called microparticles/MPs) that contain mitochondria, which represent the energy producing motors for living cells. We have also discovered that MPs preferentially bind and internalize into leukemia […]

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Epigenetic Regulators of Anticancer Drug Response

The effectiveness of cancer drugs depends on several factors which are governed by the genetic and ‘epigenetic’ code of cancer cells. The epigenetic code comprises those heritable modifications that bookmark DNA and DNA-associated proteins to guide the expression of genetic attributes without changing the DNA sequence. This epigenetic code is written, read, and erased by […]

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Epigenetic Regulators of Anticancer Drug Response – Year two

The effectiveness of cancer drugs depends on several factors which are governed by the genetic and ‘epigenetic’ code of cancer cells. The epigenetic code comprises those heritable modifications that bookmark DNA and DNA-associated proteins to guide the expression of genetic attributes without changing the DNA sequence. This epigenetic code is written, read, and erased by […]

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Development of new methods for screening bioilogics by means of Capillary Electrophoresis (CE) coupled with Mass-Spectrometer (MS) via novel Open Port Probe Sampling Interface (OPP)

The methods for screening complex biological samples found wide application in pharmaceutics, forensic science and medical science. The majority of these methods involve several analytical techniques coupled together in order to maximize the efficiency of the analysis. For example, the combination of Capillary Electrophoresis (CE) with Mass Spectrometry (MS) creates a new analytical platform (CE-MS) […]

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Development of new methods for screening bioilogics by means of Capillary Electrophoresis (CE) coupled with Mass-Spectrometer (MS) via novel Open Port Probe Sampling Interface (OPP) – Year two

The methods for screening complex biological samples found wide application in pharmaceutics, forensic science and medical science. The majority of these methods involve several analytical techniques coupled together in order to maximize the efficiency of the analysis. For example, the combination of Capillary Electrophoresis (CE) with Mass Spectrometry (MS) creates a new analytical platform (CE-MS) […]

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Development, implementation and evaluation of a bulk tank milk surveillance program for infectious and emerging diseases on Ontario dairy farms

The spread of endemic and emerging infectious diseases continues to plague the dairy industry. The convergence of human, animal, and ecosystem interactions results in emergence and re-emergence of diseases in dairy cattle such as salmonellosis and anaplasmosis. Adding to the mix, frequent buying of cattle contributes to rapid dissemination of infectious diseases in dairy cattle. […]

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Measuring the fate of naphthenic acids in wetlands using Polar Organic Chemical Integrative Samplers and Solid-Phase Microextraction – Year two

Treatment wetlands have emerged as a potential treatment option for oil sands process-affected waters (OSPW) produced from bitumen extraction by the oil sands industry. Of particular interest is the removal of naphthenic acids (NAs), which are widely acknowledged as the primary constituents of toxicity in OSPW. Studies have demonstrated the capacity for NA removal in […]

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Beyond Covid-19: infusing interactive multi-sensory physical movements to a new model of children’s adaptation for the new normal

The Mental Health Commission of Canada indicates that approximately 1.2 million children and youth in Canada are suffering with mental illness; however, only 20% receive proper treatment. Studies have shown that the pandemic impacts children’s physical and mental health, and children are now experiencing increased mental health and physical challenges as a result of COVID-19. […]

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Beyond Covid-19: infusing interactive multi-sensory physical movements to a new model of children’s adaptation for the new normal – Year two

The Mental Health Commission of Canada indicates that approximately 1.2 million children and youth in Canada are suffering with mental illness; however, only 20% receive proper treatment. Studies have shown that the pandemic impacts children’s physical and mental health, and children are now experiencing increased mental health and physical challenges as a result of COVID-19. […]

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Quantifying community-level responses to anthropogenic landscape disturbance and management using multi-array camera trap data

Habitat loss through anthropogenic landscape disturbance is one of the leading drivers of biodiversity loss, yet activities such as resource extraction and agriculture play a vital role in the global economy. Understanding impacts of such disturbances, through robust environmental monitoring protocols, is key to maintain a balance between economic growth and environmental sustainability. Cost-effective monitoring […]

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Role of cannabinoids on fast-inactivation of cardiac Nav channels

Cannabinoids are natural products derived from the Cannabis sativa plant (commonly known as marijuana). Cannabidiol (CBD), the main non-psychotropic cannabinoid is reputed to have medicinal benefits and is approved for the treatment of two seizure disorders. Other non-psychotropic cannabinoids, like cannabinol and cannabigerol, are less studied. We previously found that CBD both directly and indirectly […]

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