Enabling next generation cardiac therapeutics with genetic engineering and novel in vivo models for cardiomyocyte transplantation

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to […]

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Enabling next generation cardiac therapeutics with genetic engineering and novel in vivo models for cardiomyocyte transplantation – Year two

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to […]

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Silicon Quantum Dot Trace Explosive Sensor

The rapid detection of high energy materials (i.e., explosives) and chemical, biological and radioactive (CBR) agents have received substantial attention because of its obvious importance to security and forensics. Applied Quantum Materials Inc. (AQM) is developing a straightforward luminescent quantum dot paper- and/or cloth-based detection system that shows instantaneous optical detection of nitro-based explosives in […]

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Silicon Quantum Dot Trace Explosive Sensor – Year two

The rapid detection of high energy materials (i.e., explosives) and chemical, biological and radioactive (CBR) agents have received substantial attention because of its obvious importance to security and forensics. Applied Quantum Materials Inc. (AQM) is developing a straightforward luminescent quantum dot paper- and/or cloth-based detection system that shows instantaneous optical detection of nitro-based explosives in […]

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Interaction between cannabinoid drugs and sodium channels in diabetes/high glucose induced oxidative stress, neuroinflammation, and neurotoxicity

Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes […]

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Interaction between cannabinoid drugs and sodium channels in diabetes/high glucose induced oxidative stress, neuroinflammation, and neurotoxicity – Year two

Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes […]

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Management and conservation of polar bears in Davis Strait: An integrated population modeling approach to estimating population size, growth rate and Total Allowable Harvest of a priority species in Nunavut, Canada.

Estimates of population size and structure of the Davis Strait polar bear population are uncertain due, in large part, to the prohibitive costs of conducting regular aerial surveys. In recent years, Inuit have indicated that increased bear abundance has resulted in public safety concerns. In addition, Inuit believe that polar bears have negatively impacted other […]

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Management and conservation of polar bears in Davis Strait: An integrated population modeling approach to estimating population size, growth rate and Total Allowable Harvest of a priority species in Nunavut, Canada – Year two

Estimates of population size and structure of the Davis Strait polar bear population are uncertain due, in large part, to the prohibitive costs of conducting regular aerial surveys. In recent years, Inuit have indicated that increased bear abundance has resulted in public safety concerns. In addition, Inuit believe that polar bears have negatively impacted other […]

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Understanding Disengagement from Early Psychosis Intervention Services

While the effectiveness of early psychosis interventions (EPI) for young people with first-episode psychosis has been well-established, research suggests that almost one-third of patients disengage from services. Although lack of family involvement and substance use have arisen as consistent factors associated with EPI disengagement, many other factors remain unexplored. Furthermore, few studies have explored patient […]

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Understanding Disengagement from Early Psychosis Intervention Services – Year two

While the effectiveness of early psychosis interventions (EPI) for young people with first-episode psychosis has been well-established, research suggests that almost one-third of patients disengage from services. Although lack of family involvement and substance use have arisen as consistent factors associated with EPI disengagement, many other factors remain unexplored. Furthermore, few studies have explored patient […]

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Interfacial Engineering of High Energy Density and Safe Solid-State Li Metal Batteries for Electric Vehicle Applications

Lithium-ion batteries (LIBs) have become a key player in the growing need for electric vehicles (EVs). State-of-the-art LIBs, using liquid electrolytes, still have significant challenges in their safety, lifespan, and energy density. Accordingly, solid-state lithium metal batteries (SSLBs) have recently been attracting increasing research and industrial attention due to their ability to overcome intrinsic disadvantages […]

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Interfacial Engineering of High Energy Density and Safe Solid-State Li Metal Batteries for Electric Vehicle Applications – Year two

Lithium-ion batteries (LIBs) have become a key player in the growing need for electric vehicles (EVs). State-of-the-art LIBs, using liquid electrolytes, still have significant challenges in their safety, lifespan, and energy density. Accordingly, solid-state lithium metal batteries (SSLBs) have recently been attracting increasing research and industrial attention due to their ability to overcome intrinsic disadvantages […]

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