Raman spectroscopy is a powerful analysis technique in which a chemical sample is illuminated by a laser and the molecular identity of the sample is revealed by measuring the precise wavelength shifts of the reflected laser photons. Raman methods are being adopted in many different business sectors, but they are particularly well-suited to the requirements […]

Many new pharmaceuticals are based on large biomolecules like proteins. Even small differences in the protein structure can cause significant changes in the efficacy and safety of these drugs. Furthermore, these large molecules are difficult to characterize without advanced instrumentation and methods. Current technologies still struggle with robustness and reproducibility. This study aims to introduce […]

Many new pharmaceuticals are based on large biomolecules like proteins. Even small differences in the protein structure can cause significant changes in the efficacy and safety of these drugs. Furthermore, these large molecules are difficult to characterize without advanced instrumentation and methods. Current technologies still struggle with robustness and reproducibility. This study aims to introduce […]

Pharmacotherapy is one of the primary treatments for psychiatric disorders. Given the variation in individual response, and the current trial-and-error treatment, a more personalized approach is needed. The Mitacs Elevate postdoctoral trainee will gain direct experience with all aspects of using pharmacogenetic testing to personalize medication prescriptions for patients, and the commercialization of the test. […]

Pharmacotherapy is one of the primary treatments for psychiatric disorders. Given the variation in individual response, and the current trial-and-error treatment, a more personalized approach is needed. The Mitacs Elevate postdoctoral fellow project involves the use of pharmacogenetic testing to personalize medication prescriptions for patients, and the commercialization of pharmacogenetic testing. A main component of […]

Our group developed a new generation of chip-based small-scale devices for continuous purification of chemicals and nanoparticles, based on the interactions of analyte with multiple types of driving forces in an electro-fluid-dynamic (EFD) system. One series of the purification devices has the electric field in parallel with the fluid flow direction (E?F), while the other […]

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and treatment of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life from […]

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and treatment of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life from […]

Obesity, type 2 diabetes (T2D) and heart diseases have skyrocketed. Controlling glucose usage and insulin balance can substantially decrease the morbidity and improve the quality of life in affected individuals. Dysfunctional insulin action and energy balance in the body is associated with excessive non-adipose fat storage, particularly in the liver, and elevated circulating lipids, which […]

Closing the carbon cycle by utilizing CO2 as a feedstock for producing new fuels such as Methanol and Ethanol is an appropriate intermediate step towards a carbon-free future. Recently some researches on new nano-catalysts have increased the hope of bringing this technology to the market. While the reaction mechanisms are not elucidated, the present study […]

PROTACs are bifunctional molecules that allow the elimination of target proteins in the cells. Despite the advantages of this early field, the area of small molecules PROTACs presents some drawbacks, in particular, the long and tedious syntheses of the central linker. Secondly, the variety of those linkers is quite scarce, as poly-ether or alkyl chains […]

Les PROTACs sont de nouvelles molécules thérapeutiques ayant pour but de soigner certaines maladies grave comme les cancers. Ces composés sont des molécules linéaires constitués de trois composants principaux : une extrémité permettant de repérer la cible, une autre extrémité permettant de causer la dégradation de cette cible, et enfin un linker reliant les deux. […]