Muscle stem cell-niche interactions predicted in silico

Skeletal muscle, an essential organ system making up 30-40% of total body mass, is unique in that it allows for the body’s voluntary movement. It is solicited and stressed daily and consequently possesses the remarkable ability to regenerate in response to injury due to a special population of cells named muscle stem cells (MuSCS). At […]

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Identifying putative antibiotic resistance genes (ARGs) in the ancient oral cavity from the Industrial Revolution

This project plans to use dental calculus (miniralised plaque) samples to acquire a better understanding of the development of antimicrobial resistance (AMR) in the human oral microbiome. This will be the first metagenomic study regarding antibiotic resistance genes dating back to the Industrial Revolution (c. 1750-1850). We expect to detect some evidence of ARGs based […]

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L’évolution de l’identité francophone en Bulgarie depuis 1993

Depuis son institutionnalisation en 1970, la Francophonie n’a eu de cesse de faire évoluer ses caractéristiques identitaires. Elle est ainsi passée de centrer sur la France à une multitude de centres au sein de l’ensemble des pays francophones, et de culturelle à politique et diplomatique. Le projet de recherche s’attache alors à identifier, à travers […]

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Effects of a parent intervention with a growth mindset approach on the quality of parent-child interaction

The quality of parent-child interactions is among the most important active ingredients of early language development. Many interventions, which vary in approach, content and format, focus on improving the quality of these interactions between children and their caregivers in order to promote early language development. Understanding the relationship between the characteristics of these interventions and […]

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Beyond accuracy: robustness and generalization properties of biologically plausible learning rules

The overarching goal of my research is to investigate how the brain learns in order to develop brain-inspired learning algorithms that will reduce the computational cost for many machine learning applications. The standard learning algorithm (or learning rule) for training artificial neural networks (ANNs) can be extremely costly in terms of computation and storage, driving […]

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Improving Measurement for Near Term Quantum Computers

The ability to simulate chemistry accurately allows for significant developments in many fields such as material and drug discovery. Unfortunately, the underlying equations that describe chemistry become exponentially harder to solve as we increase the size of the system. This makes it impossible for us to accurately simulate useful molecules on classical computers. A potential […]

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Derivation of biased bitopic ligands for class A GPCRs – an NMR approach

Our goal is to employ a host of new compounds, made by the applicant in her lab in Brazil, for drug discovery studies at the University of Toronto. Specifically, the host uses a technique called Nuclear Magnetic Resonance (NMR) to obtain signatures of drugs or ligands. These signatures can identify those compounds which bind strongly […]

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La coopération inter-organisationnelle: La bête noire de la paix africaine

Cette recherche a pour but de contribuer à la recherche sur la coopération internationale et plus précisément la coopération inter-organisationnelle dans le cadre des opérations de la paix en Afrique. Les conflits étant de plus en plus nombreux et complexes, la coopération inter-organisationnelle est devenue extrêmement sollicitée, multipliant la présence d’acteurs dans les régions affectées […]

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Intergenerational Impacts of Transport Poverty in Canada

The aim of this project is to assess the long-term impacts of transport poverty in Canada using mixed methods approach. Transport poverty is the combined effect of transport disadvantage (including but not limited to inadequate public transport options, poor public transport accessibility, not owning or having access to car, perception of safety) and various socio- […]

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Photo-Stabilization of Polymers Using Graphene

The main challenge in using polymers in outdoor application is to extend their life time and make them stable against sunlight. Recently, graphene has been suggested as a new type of polymer photo-stabilizer to replace toxic and harmful photo-stablizers commonly used. The main challenge is to understand protective mechanisms of its action. Is it a […]

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Sequence comparison of SARS coronavirus 2 (SARS-CoV-2) outbreaks in mink occurring in North American/Canadian- and Danish farmed mink, and investigation into the post infection the antibody response

Aim of the study: The aim of this study is to compare the SARS-CoV-2 sequencing data available from the north American/Canadian SARS-CoV-2 outbreaks in mink to the Danish SARS-CoV-2 outbreaks in mink, and compare genetic similarities. Moreover, a secondary aim is to investigate the antibody response in relation to SARS-CoV-2 outbreak in Canadian mink to […]

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