This program is to analyze the regulation of cell cycle progression and the mechanism of chromosome segregation with regard to Kinesin5 and Kinesin8 families. Defects in these processes can result in the formation of aneuploid cells, a hallmark of many solid cancers. Thus, insights into the function and regulation of Eg5 and Kif18A (one protein […]

Roughly 4-6% of the general population suffers from excessive daytime sleepiness. Central hypersomnolence disorders are characterized by incurable constant occurrence of this daytime sleepiness in combination with a disturbed sleep-wake cycle, resulting in severely impaired daytime functioning. Central hypersomnolence disorders are normally diagnostically divided in two types of narcolepsy and idiopathic hypersomnia. While narcolepsy type […]

The research for this project will culminate in a final paper examining the Tropenmuseum’s new temporary collection Afterlives of Slavery, as a case study to consider efforts to transform the purpose and relevancy of museums. The exhibition, which recently opened in 2017, explores the Netherlands’ ties to slavery and colonialism, revealing how these histories continue […]

Endothelial cells( ECs) form the inner surface of blood vessels. If they break down, they may lead to vascular disease, heart failure,and high blood pressure. Endothelial cells(ECs) functions are regulated by permanent mechanical stresses such as shear stress and pressure from blood stream. When some cells are damaged, the adjacent cells are induced by them, […]

Infrared (IR) spectroscopy is a diverse, powerful and nondestructive sensing technique amenable to a wide variety of applications. The sensitivity of IR measurements can be greatly improved by local electromagnetic field enhancements provided by nanoscale metallic structures. We propose a novel platform for enhanced IR spectroscopy, consisting of a bowtie structure composed of a nanoscale […]

Printable electronics is a new advanced manufacturing technology, which allows a low-cost and simple fabrication of optical devices. The production consists of three main steps: choosing the materials, printing, and sintering. At first, a metallic ink and a substrate must be chosen. The second step is a printing which could be realized even with a […]

the physics-based modeling of the impact of road pavement characteristics on UHI can be complex and inaccurate. On the other hand, advances in data science and machine learning along with the ever-increasing computational power offer data-driven modeling opportunities that are relatively easy to setup. In recent years, with the rise of the Internet of things […]

OPTIC is a state of the art piece of research software designed to allow computers to autonomously plan complex tasks, such as construction projects, rail timetables and other planning and scheduling tasks. Currently, OPTIC handles the scheduling process using a technique known as Mixed Integer Programming (MIP). In this project, the aim will be to […]

In traditional control systems such as industrial plants, automobiles, HVAC systems, etc. consist of a single dynamical system that is controlled by a single controller. Such systems are referred to as centralized control systems. Many of the modern control systems such as networked control systems, Internet of Things, mobile robotics, vehicular platoons, and smart grids […]

Stroke is the most frequent neurological disorder leading to long-term disability by an impairment in movement control. In this project we aim to quantify the damage to a patient´s brain with a newly developed method: Tractography-based Lesion Assessment Standard (TractLAS). This tool provides a patient-specific quantification of the whole-brain structural network damage caused by stroke. […]

In this proposed research project, I plan to study the lived experience of migration, and the factors underlying psychological distress, among international students in Montreal, Canada. I propose to analyze archival data and conduct interviews in order to accomplish this. Upon completion of the project, I will return to Japan and conduct a parallel study […]