The effective antimicrobial treatment of bone infections / osteomyelitis are often hampered by the secretion of beta-lactamase enzymes that inactivate the beta-lactam ring of otherwise effective penicillins and related antibiotics. To neutralize enzyme activity, beta-lactam antibiotics will often be co-administered with beta-lactamase inhibitors, such as Tazobactam. However, the systemic introduction of beta-lactamase inhibitors may not […]

The purpose of this project is to contribute to our understanding of the development of Yogacara (Jp. Hosso) thought in pre-modern Japan between Heian and Kamakura periods (794-1333). To do so, it examines the writings of the Hosso monk-scholar Jokei (1155-1213), a neglected yet important reformer who lived in an era marked by political instability […]