Prostaglandin E2 stimulates bone formation in vivo and exerts its effects through the EP4 receptor. Unfortunately prostaglandin E2 and agonists for the EP4 receptor also cause unacceptable systemic side effects which have limited their clinical use as anabolic agents. We developed novel bone-targeting prodrugs that can deliver EP4 agonists selectively to bone and liberate active […]

Prostaglandin E2 stimulates bone formation in vivo and exerts its effects through the EP4 receptor. Unfortunately prostaglandin E2 and agonists for the EP4 receptor also cause unacceptable systemic side effects which have limited their clinical use as anabolic agents. We developed novel bone-targeting prodrugs that can deliver EP4 agonists selectively to bone and liberate active […]

LGBT+ Inclusion in Schools: A discourse analysis of the nature of inclusion with in the SOGI 123 programme and the UK’s LGBT+ inclusion policies

Open, digital scholarship in the Arts and Humanities is significant as a mechanism of Canada’s growing digital scholarly infrastructure for facilitating public access and engagement with research. But the path to adopting open, digital scholarship on a national scale has been challenging. Academic organizations like the not-for-profit Iter Canada are committed to facilitating the engagement […]

Northwest Hydraulic Consultants Ltd. (NHC) is often involved in the restoration and design of steep streams. To date when assessing these river channels, NHC has relied upon experimental results conducted with fixed vertical river banks and a series of assumptions have been used to figure out how to make river channels with sloped banks. These […]

Northwest Hydraulic Consultants Ltd. (NHC) is often involved in the restoration and design of steep streams. To date when assessing these river channels, NHC has relied upon experimental results conducted with fixed vertical river banks and a series of assumptions have been used to figure out how to make river channels with sloped banks. These […]

As the number of im/migrant women in British Columbia (BC) continues to grow – the majority of whom are of reproductive age- there is a need to ensure that im/migrant women have adequate access to healthcare, including sexual health services. While BC is one of Canada’s top destinations for im/migrants, robust evidence regarding im/migrant women’s […]

Osteoarthritis is the most common form of joint disease affecting over 80% of the human population above 75 years old and burdening health organizations worldwide. Osteoarthritis is characterized by progressive joint degeneration resulting in chronic pain and loss of joint function. Currently there is no cure for osteoarthritis; available treatments are only symptomatic targeting pain […]

British Columbia’s sablefish fishery is among the most highly valuable fisheries in Canada. In the early 1990s, mainland inlets were closed to commercial fishing because young sablefish were thought to grow in these protected areas before moving to the offshore areas where the fishery operates; we will look at movement patterns of sablefish within BC […]

Honey bee colony health and productivity is intrinsically linked to the quality of the queen. Unfortunately, queen quality is compromised by stressors such as extreme temperatures and pesticide exposure. When queens are heat- and cold-shocked, the viability of their stored sperm drastically decreases, causing colonies to dwindle, produce less honey, and ultimately fail. Pesticide exposure […]

In today’s world, there is an increasing need for convenience and customizability in food products, though these may be competing priorities. Food on the go, such as protein bars and cereal bars, are a popular choice for convenience, but despite the enormous variety of food bars for sale, there is still a need for increased […]

Automation is generally perceived as the application of physical robots to replace the human workforce to complete a specific task. However, automation can also appear in the design process where it replaces the repetitive computations and lookups by a human. In the latter case, automation reduces the risk of human error and highly increases the […]