Uncovering the role of ketogenesis in SGLT2 inhibitor-mediated fatty liver disease

Fatty liver disease, the most common complication of type 2 diabetes (T2D), affects 1 in 5 Canadians. If not managed or treated, a proportion of patients with fatty liver disease may develop the irreversible phases of liver failure, and hepatocellular carcinoma. A new class of drugs, SGLT2 inhibitors (SGLT2i), has been approved by Health Canada […]

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Peptide-based material for heart muscle repair

With over 17 million deaths per year, heart diseases remain the top cause of mortality worldwide. Surgeries such as bypass restore blood supply and save lives. However, after a heart attack the capacity of the heart to pump blood is reduced. In Canada, over 2 million people aged 20+ live with heart disease, costing the […]

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Focused Ultrasound for Intraocular Hemmorhage

Intraocular hemorrhage is the most common cause of sudden vision loss from advanced diabetic eye disease. This occurs when blood from diseased retinal vasculature leak into the normally clear, gel-like substance in the eye called the vitreous, obscuring vision. The current management guidelines for these patients is a period of modified bedrest (up to 4 […]

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Using artificial intelligence to screen children suspected with listening difficulties

The goal of this project is to create a cutting-edge screening tool for children with listening difficulties, which can have a profound impact on their academic performance, social development, and overall well-being. Despite the current assessment process, which is time-consuming and requires extensive training and experience, early identification and intervention are critical for these children […]

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Development and Evaluation of Antimicrobial Agents for Improving the Lifetime of Metalworking Fluid

Metalworking fluid is a widely used lubricant during the processing of metal (drilling, cutting, grinding, etc.). Even though it has been applied to industries for decades, microbial contamination is still considered a major problem during its application. The microbial contaminations not only reduce the effectiveness of the lubrication but also cause potential health issues. In […]

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Artificial Intelligence for Prostate Cancer Detection using Ultrasound

Prostate cancer is the most common cancer in Canadian men, and early and accurate diagnosis is critical for successful treatment. The proposed research aims to develop AI-powered tools to improve the accuracy of prostate cancer detection using ultrasound technology. In collaboration with Exact Imaging, we will develop AI tools that can analyze images from the […]

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Investigating spatial and temporal nutrient trends in the St. Lawrence River

Increasing our knowledge of Canada’s lakes and rivers is essential to maintain healthy aquatic ecosystems and to ensure human enjoyment of these waterbodies. This project will work with the local Indigenous community, Mohawk Council of Akwesasne, to better understand trends in nutrient levels along the Upper St. Lawrence River. Human activities, including agriculture, industry, and […]

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Distributed Extremum Seeking Control Using Observer-based Methods

In this project, we propose a new technique for controlling the formation of high-altitude balloons. Instead of using traditional high-pass filters, we suggest using high-gain observers to improve the accuracy and effectiveness of extremum-seeking control. Our research on this multi-agent approach aligns with the main objectives of Stratotegic Inc, which focus on the research and […]

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An integrated and adaptive study examining central and peripheral mechanisms of chronic pain in knee osteoarthritis patients

It has been estimated that 300 million people worldwide have osteoarthritis (OA) and this has increased by 97% over the past 25 years. The pain and loss of mobility experienced by people with knee OA can seriously reduce quality of life, while pain management causes significant healthcare spending. Unfortunately, the pain associated with OA is […]

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