GeneVa – Computing Metaoblic Valves on a Genetic Level

Bioprocesses are indispensable for the sustainable production of high value chemical compounds from renewable feedstock. In many processes, genetically engineered strains with a modified metabolism are used. Boosting the performance of such a production host can be essential to make a bioprocess profitable. Computational strain design provides methods to identify interventions in the microbial metabolism […]

Read More
Advancing municipal natural asset management through monitoring & engagement

Canadian local governments are seeking new strategies to deliver their core services in more financially and environmentally sustainable ways, including turning to infrastructure asset management as a key tool to manage infrastructure. Municipalities are increasingly recognizing that natural assets such as aquifers, forests, streams and foreshores can provide equivalent or better services to many engineered […]

Read More
Optimized Design of Building-Integrated Photovoltaic Sunshades

The proposed project involves the creation of a computational framework to optimize the design of building integrated photovoltaic sunshades. Such shades would allow improved lighting conditions within the indoor environment, while generating power through the photovoltaic panels. The design framework takes in design constraints such as the allowable size of the shade, the location and […]

Read More
A New Way Forward: Using Biocultural Approaches to Conservation in Key Biodiversity

Canada is a signatory to global conservation agreements to increase the number and coverage of protected areas in the country. Key Biodiversity Areas (KBAs) are a science-based planning tool that can help governments, industry, environmental groups and Indigenous Nations target the right places to protect in terms of habitat for wildlife and to ensure these […]

Read More
Meta-information Extraction from Large-scale Streaming News for Entity-level Media Intelligence and Reporting

Gnowit is an Ottawa-based information services company that employs artificial intelligence and machine learning to automate the process of monitoring web sources at scale to provide real-time briefings and notifications for the purposes of competitive intelligence, evidence-based policy research and media monitoring. The company currently monitors more than 40 thousand web sources and generates atleast […]

Read More
Meta-information Extraction from Large-scale Streaming News for Entity-level Media Intelligence and Reporting – Year two

Gnowit is an Ottawa-based information services company that employs artificial intelligence and machine learning to automate the process of monitoring web sources at scale to provide real-time briefings and notifications for the purposes of competitive intelligence, evidence-based policy research and media monitoring. The company currently monitors more than 40 thousand web sources and generates atleast […]

Read More
Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction

Mitochondria are critical producers of energy and are the platform for various metabolic reactions that support cellular health. Mitochondria suffer from a variety of damage as a consequence of housing these reactive pathways. In order for cells and organisms to survive this damage, dysfunctional mitochondria are removed from the cell in a process termed mitophagy. […]

Read More
Biomimetic functional coating for flux control

We would like to develop slippery liquid infused surfaces for molding applications. Molding technology is of great importance in industry and understanding the wetting behavior of molding liquids (polymers/metals) is of fundamental interest and non-trivial as well because of the involved phase transition from liquid to gel/solid upon cooling. Thus, both wetting and post solidification […]

Read More
Development and integration of feature detection algorithms for metal-based direct deposition processes

Metal-based direct energy deposition processes, such as robotic welding and laser powder fed additive manufacturing, ideally require feedback sensing of the deposition quality using vision detectors. Image processing algorithms are challenging to develop due to changing process operating conditions. Despite challenges, implementing in-process image processing algorithms is beneficial for traceability and quality assurance, for calibrating […]

Read More
Development of assays to detect biostasis activity in synthetic intrinsically disordered proteins

Tardigrades are among the hardiest organisms known, with some species being able to withstand high doses of radiation, desiccation, lack of nutrients, and extremes in both pressure and temperature. Humans, conversely, are extremely susceptible to such conditions. The tardigrade’s ability to readily survive for long periods in the harsh environment of space has been well […]

Read More
Wearable Textile-Based Microfluidic Self-Powered Biosensing System

Our biofluids, like sweat, contain many solutes and metabolites that are related to our health conditions. For example, sweat glucose concentration can be noninvasively measured to represent blood glucose concentration for diabetes management. Imagine your clothes can not only wick and adsorb your sweat to keep you dry but also collect and analyze your sweat […]

Read More
Printability of H13 tool steel by powder-fed laser additive manufacturing

The scope of this research is to provide a comprehensive recipe for powder-fed laser additive manufacturing (PF-LAM) of H13 tool steel. The H13 components manufactured by PF-LAM can potentially show superior mechanical properties as compared to H13 steel manufactured by conventional methods; however, the process optimization is requisite to achieve the additively manufactured H13 tool […]

Read More