Despite the power of gene therapy, its successful application to medicine has been diminished due to: (i) high toxicities and potentially fatal adverse effects; (ii) poor transgene expression in target cells; and (iii) extensive vector degradation. While viral vectors greatly improve efficiency, they sometimes lead to cancers due to chromosomal integration and may suffer from […]

Despite the power of gene therapy, its successful application to medicine has been diminished due to: (i) high toxicities and potentially fatal adverse effects; (ii) poor transgene expression in target cells; and (iii) extensive vector degradation. While viral vectors greatly improve efficiency, they sometimes lead to cancers due to chromosomal integration and may suffer from […]

Efficient pumping function of heart depends on receiving oxygen and nutrients through heart’s specific blood vessels called coronaries. In case of coronary stenosis (e.g. plaques formation on their inner walls), the heart muscle cannot function normally and may be permanently damaged. Three treatment strategies are broadly available that include medications, coronary stent placement and coronary […]

Efficient pumping function of heart depends on receiving oxygen and nutrients through heart’s specific blood vessels called coronaries. In case of coronary stenosis (e.g. plaques formation on their inner walls), the heart muscle cannot function normally and may be permanently damaged. Three treatment strategies are broadly available that include medications, coronary stent placement and coronary […]

Indoor air quality has received immense attention in past decades, considering it is more heavily polluted than outdoor environments. People generally spend more than 80% of their time indoors, which contributes to a higher risk of inhaling pollutants. Air cleaning is the most feasible way to improve indoor air quality. Most of indoor air – […]

The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individual’s quality of life and increases the likelihood of […]

The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individual’s quality of life and increases the likelihood of […]

This proposed project focuses on American ginseng (AmG), a natural herb native to Canada that has been used as a traditional medicine for many generations. Southern Ontario has become the World’s largest producer of AmG with annual sales of over $400M at the farm gate. Polysaccharides (PS) are a major active component of AmG showing […]

This proposed project focuses on American ginseng (AmG), a natural herb native to Canada that has been used as a traditional medicine for many generations. Southern Ontario has become the World’s largest producer of AmG with annual sales of over $400M at the farm gate. Polysaccharides (PS) are a major active component of AmG showing […]

Urbanization continues to drive the land conversion from natural areas to urban uses dominated by impermeable surfaces. This conversion has direct and indirect impacts on ecosystem services that are critical for a sustainable and resilient ecosystem as well as human wellbeing. Habitat removal and fragmentation accelerate biodiversity loss in urban landscapes. Additionally, climate change exacerbates […]

Urbanization continues to drive the land conversion from natural areas to urban uses dominated by impermeable surfaces. This conversion has direct and indirect impacts on ecosystem services that are critical for a sustainable and resilient ecosystem as well as human wellbeing. Habitat removal and fragmentation accelerate biodiversity loss in urban landscapes. Additionally, climate change exacerbates […]

Information technologies that can provide health professionals detailed patient information in ‘real time’ can improve patient experience, quality of care, and staff workload. However, to date, Canada’s health care system has been challenged by limited adoption and implementation of new information technologies that hold great promise for achieving health system transformation. To address these challenges, […]