Risk-based evaluation and optimization of friction devices for seismic retrofits of non-ductile building structures in Canada

Canada’s early-designed public buildings (i.e., schools and hospitals) are at significant risk of seismic damage and collapse. The installation of seismic protective devices, such as friction devices designed and manufactured by Quaketek Inc, offers a viable strategy to mitigate the seismic risk of building structures. However, the practical use of friction devices has commonly relied […]

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Communication, diffusion et maillages: développement d’outils communicationnels pour la transition socioécologique

La demande a pour but d’explorer et de mettre en place des outils de communication efficaces pour diffuser et transmettre le rêve collectif sur les enjeux de transition socio-écologique. En partenariat avec le projet du Grand dialogue régional pour la transition au Saguenay–Lac-Saint-Jean et Eurêko!, œuvrant tous deux dans le domaine de l’environnement et de […]

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Syncrétisme royal et divin dans la numismatique d’Argilos

Bien que les monnaies aient été largement remplacées ces dernières années par des systèmes informatiques sous forme de crédit, l’importance et la valeur d’une unité de transaction restent des éléments de très grande importance, et ce, autant pour nous aujourd’hui que pour les Grecs de l’Antiquité. Les unités de transaction en elles-mêmes datent de plusieurs […]

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Development of an Integral Strategy for Model-based Dose Adaptation in Chemotherapy Year Two

Drug models describe the relationship between exposure (or pharmacokinetics), response (or pharmacodynamics) for both desired and undesired effects, and individual patient characteristics. In this project, drug models will be used to propose an integrated dose adaption strategy for cancer treatment. This strategy has a particular clinical value for our partner (InVentiv Health Clinical, a Contract […]

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Using high-throughput mapping techniques to reveal mechanisms of vocal learning

Understanding how humans and non-human animals communicate with each other continues to be a central question in neuroscience. Songbirds serve as powerful animal models for this endeavor because they learn their vocalizations (“songs”) in a manner that resembles how humans learn to speak and because vocal learning in songbirds is regulated by discrete brain circuits […]

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Improving the performance of manufacturing processes at GE Bromont by using artificial intelligence and pattern recognition

The products manufactured at GE Bromont go through a series of processes that produce the specific characteristics of each product according to required specifications. The number of these characteristics is very large, and several characteristics are dependent on the others. This reality makes the use of traditional statistical techniques for quality control of products laborious […]

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Identification of early markers of developmental epigenetic anomalies in bovine production

Bovine production uses a combination of Assisted Reproductive Techniques (ARTs) to improve yield and reduce generation time. In bovine production and in clinical settings, ARTs are associated with elevated rates of developmental disorders in offspring, leading to animal distress, high costs and delayed results. These include Large Offspring Syndrome (LOS) and musculoskeletal anomalies, reported to […]

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Stability of Protein-PEDOT:PSS Coating for Implantable Electrodes

Medical devices that are implanted into the human body allow for continuous medical monitoring and intervention, such as stimulation, recording, and drug delivery. Cardiac pacemakers and insulin pumps are examples of novel technology implanted for long-term treatment. For the treatment of neurological disorders, recent advances in neuroengineering consider the use of implantable electrodes. However, these […]

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Agglomération industrielle en Canada : application et développement des méthodologies spatiales et spatio-temporelles

Les choix de localisation des entreprises ainsi que les agglomérations industrielles sont un sujet clé dans le développement régional et l’aménagement territorial en raison des effets externes générés par ces mécanismes qui peuvent avoir un impact sur les inégalités régionales et également sur la productivité des firmes. En lien avec notre réalité actuelle, ces mécanismes […]

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Studies of CNNM-TRPM7 complexes

It has recently been shown that the tumour suppressor CNNM and TRPM7 bind each other and are coordinately regulated. We propose to determine the structure and function of the complex using cryoelectron microscopy and ion transport assays. A PhD student from the Gehring laboratory will spend four months working in the Runnels laboratory designing and […]

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