Tractography of the central olfactory pathway in prodromal Alzheimer’s disease

The diagnosis of Alzheimer’s disease is currently made when the criteria for dementia are met, i.e. when the cognitive deficits are severe enough to interfere with the person’s autonomy. Thus, it is important to find early markers of Alzheimer’s disease in order to be able to intervene before the dementia stage, in prodromal stages of […]

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An New Airframe Design Methodology for Safety-Critical UAV

Unmanned aerial vehicle (UAV) technologies have the potential to contribute to Canada’s resilience against climate and health crises and change people’s daily lives. Specific examples of use could be firefighting, land erosion mapping, the fast delivery of vaccines in the north of Canada, flying ambulances, defibrillators for emergency calls. These applications are challenging in many […]

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Aptamer-facilitated Virus Shielding (Apta?ViSh) Technology and Aptamer-facilitated AntivirusShielding (Apta-AntiviSh) Technology to extend the in vivo action of oncolytic viruses. Year One

This project aims to develop an aptamer?based technology to enhance the in?vivo survival of oncolytic viruses and thus the efficiency of virotherapy. Oncolytic viruses (OVs) can selectively replicate in tumor cells, leading to lysis of the tumor. OVs are particularly effective against metastatic cancers, which are especially difficult to treat conventionally. However, OVs can be […]

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Study of delta Scuti stars with probable magnetic field

Four cycles of observations with the space telescope TESS have provided high-quality photometric data and have led to discovery of a group of delta Scuti stars that show pulsations at high frequencies (nu> 40 c/d) which are similar to the pulsations of roAp stars. Recent discovery of magnetic field in delta Scuti star HD41641 suggests […]

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Generation of synthetic images of chest radiography with chronic obstructive pulmonary disease using artificial intelligence techniques

The main purpose of this research is to propose a strategy to generate synthetic chest x-ray images from data of clinical interest. The generated images should visually reproduce lung disease based on the selected input characteristics. This requires the processing and analysis of images using algorithms that identify the most relevant characteristics and variables to […]

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Development of an Electrodynamic Simulation Toolbox for Nanophotonics

Finite Difference Time Domain (FDTD) simulations allow researchers to model complex devices and systems based on integrated micro/nano structures. The electrodynamic behaviour predicted by FDTD simulations match very well with the real physical systems, which significantly accelerates the development of novel devices. However, there are limitations in existing FDTD techniques to model metal nanoparticles on […]

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International Criminal Court and gender-based violence

The project will analyze the genesis and stages of development of GBV-related crimes` international legal regulation. The intern will consider the legal regulation of GBV-related crimes as well as analyze ICC cases involving GBV-related issues. The main objective is to outline key problems in gender-related ICC practice and to propose possible solutions in order to […]

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Regulation of T-type calcium channel activity by targeting channel trafficking – a novel approach for pain management Year two

Current therapies to manage pain either result in side effects or are insufficient and the associated medical costs and loss of work days come pose a tremendous socioeconomic burden. We recently showed that T-type channel activity is aberrantly regulated in inflammatory and neuropathic pain by the deubiquitinase USP5, and we have begun to explore this […]

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