A novel class of DHODH inhibitors called tetrahydroindazoles was recently identified in the group of professor Sonia Lain through screening of a commercially available chemical library for activators of p53. The hit compound HZ00 is able to slow tumor cell growth in culture, an effect which was reversed upon supplementation with uridine, and had little […]

Oxidative stress and inflammation can cause neuron degeneration and lead to mental disorders such as Alzheimer’s Disease. Dementia is debilitating and poses economic burden to the patients, families, and society. Currently, no curative drugs have been developed to treat dementia. This study will be elucidating the mechanism of action and examining the anti-oxidative and therapeutic […]

Counter-streaming plasma has been featured in many experiments due to its prevalence in astronomy around supernova shocks, as well as in other lab plasma applications. These plasmas develop magnetic fields which are interesting due to their ability to accelerate particles as well as their roll in the formation of collisionless shocks. These fields are normally […]

Building a high throughput vacuum chamber for our group’s transient grading spectroscopy (TGS) project, which uses picosecond, ultrasonic laster acoustics to probe the sub-surface, thermo-elastic properties of materials. We are particularly interested to study the thermal diffusivity of material under irradiation, which requires probe depths of single microns conducted in vacuum. Our current chamber is […]

Anthropogenic inputs of phosphorus (P) from agricultural and urban activities, as well as sediment recycling (internal loading), have caused harmful algal blooms (HABs) in surface waters worldwide, including Lake of the Woods, Canada and Lake Taihu, China. HABs remain active in the Lake of the Woods and Lake Taihu even though point sources, such as […]

The goal of the project is to produce sample sets of oxide-dispersion strengthened steels, with varying compositions, using advanced manufacturing equipment and techniques. These ODS steels differ from traditional ferrous alloys as they contain nano-sized oxide particles that are dispersed throughout the body of the steel. These dispersions help strengthen the steel as they are […]

Coronary artery disease (CAD) occurs when buildup of plaque causes blockage of oxygen to reach the heart. When a total blockage occurs, this leads to heart attacks. CAD is the leading cause of death worldwide and this research will be conducted on a mutation found in a gene associated with plaque build up and analysis […]

Chlorinated organics are recalcitrant in nature and are released from industrial effluents. Advanced oxidation processes (AOPs) such as photo-catalysis are considered effective towards partial or complete degradation of toxic and recalcitrant compounds due to their non-selective nature. The current study is planned to synthesise bimetallic catalyst supported on carbonaceous waste material. The catalyst synthesized will […]

The proposed research will take place in Mt. Abu, Sirohi district of Rajasthan in Western India. Mt Abu is a batholith and consists of granite. The project will analyze the 735 Ma old Mt. Abu Granitoid batholithic pluton that is situated at the southern tip of NE trending in the Aravalli Mountain Range. The purpose […]

The proposed project is to create a virtual reality application for training healthcare staff simulataneously in performing several common neurosurgical procedures. The application will mimic an operating room including equipment and will ask the healthcare team to perform one of several neurosurgical procedures for treating hydrocephalus in pediatric patients. Data collection will be in a […]