Blood pressure increases with age in Western societies; however, populations that live as hunter-gatherers and subsistence farmers rarely develop cardiovascular disease and do not have age-related increases in blood pressure. The mechanisms responsible for the maintenance of cardiovascular health with aging are not clear. A mismatch between the conditions that postindustrialized populations inhabit – low […]

Creatine has been used as a feed additive in the poultry industry to improve energy metabolism and growth performance. However, because of creatine’s relative instability in foodstuffs, GAA has recently been explored as a potential alternative to creatine supplements. GAA is the immediate precursor for creatine production in the body. For this process, another amino […]

Ce projet de recherche vise à concevoir un modèle de prévention du COVID-19 basé sur les techniques d’Intelligence Artificielle (IA) et de l’internet des objets (IoT). Les données physiologiques seront obtenues des dispositifs intelligents et des bases de données virtuelles. Ces systèmes serviront pour le développement d’un outil de mesure et d’observance des indicateurs chez […]

Ring splints are regularly used to address swan neck deformity, boutonniere deformity as well as rheumatoid thumb due to their capacity to improve pain, function, and satisfaction. However, these ring splints do have limitations such as their price, lack of customizable attributes, and aesthetic dissatisfaction. For these reasons, 3D printing has gained traction as a […]

Cancer is a devastating disease known to be treated with chemicals causing severe side effects in the advanced stages of the disease. Among these chemicals are a group of antibiotics, called anthracyclines, used to treat a variety of cancers, including breast cancer (BC). Doxorubicin, one of the preferred anthracyclines used in BC treatment, is particularly […]

The goals of this proposal are to develop methods to identify cell subgroups in dopaminergic (DA) neuron cultures obtained by differentiation of human pluripotent stem cells (hPSC), and to exploit this information to improve existing DA neuron differentiation protocols. To realize these goals, we will leverage expertise at STEMCELL Technologies in hPSC differentiation and Simon […]

This project will focus on the research areas of smart device monitoring and the analysis of complex medical data in public health. Through the use of artificial intelligence, researchers will develop solutions that exploit large-scale sensor data, address significant challenges caused by global threats by, for example, setting early heat alerts for extreme heat waves. […]

A consequence of aging is the increased risk of neurodegenerative disease. In the pathogenesis of neurodegenerative diseases is the production of misfolded proteins which can clump together and interfere with normal cellular function. Mitochondria are highly important as they produce energy necessary for cell survival as well as regulate the controlled cell death process of […]

The COVID-19 pandemic and corresponding health, social and economic implications have resulted in significant life changes for youth. One of the most critical impacts has been on youth mental health and wellbeing. To address the mental health needs of diverse youth populations during and following the COVID-19 pandemic, the proposed internship will advance the CIHR-funded […]

An individual’s voice is unique due to a combination of their physical and social characteristics. For children who present with complex communication needs (CCN), sometimes the only functional way to communicate is by using an augmentative and alternative communication (AAC) device. AAC devices with speech output capability are known as voice output communication aids (VOCAs). […]

Bacterial resistance to aminoglycoside antibiotics is a major public health problem. The WHO (World Health organization) has highlighted the urgent need to find new treatments to fight multidrug resistance MDR bacteria, as actual drugs are less effective or inactive. This research project aims to develop new chemical compounds to restore bacterial sensitivity to antibiotics currently […]

An organism’s genome contains the information necessary for its development. Part of this information is used as “instructions” for cells to synthesize molecules called proteins, which perform most of the cell’s functions. However, over time, changes to the genomic information can occur. These changes (mutations) can have all kinds of effects: some might cause diseases, […]