Pharmacological Evaluation of a Novel Oral Amphotericin B Formulation for the Treatment of Disseminated Candidiasis: Providing New Therapeutic Alternative to the Commercial Intravenous Formulation

Amphotericin B (AmB) is the drug of choice to treat systemic fungal infection. AmB is available as parenteral infusions given over a long period of time to hospitalized patients. Our goal is to develop a novel oral formulation to enhance AmB low absorption and decrease the nephrotoxicity associated with its intravenous administration. AmB will be […]

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Optimization of Conventional and Novel Methods for Removing Carbon Dioxide from Recirculating Aquaculture Systems

Recirculating aquaculture systems (RAS) are land based fish farms that recycle the water from the fish tanks using multiple water treatment processes. Fish produce large amounts of carbon dioxide, through respiration, that needs to be removed during the water treatment process since high levels of carbon dioxide are hazardous to fish. Currently the most common […]

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Advanced design of an inverter for a new application in a telecom dc microgrid

Rapid growth of renewable energy generation and DC loads as electric vehicles and consumer electronics results in the proliferation of DC microgrids. DC microgrids are small electrical grids where energy sources and loads are connected to a main energy distribution power line using power converters. A particular example of the use of DC microgrids can […]

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Appariement hétérogène entre nuage de points LiDAR et images SAL : vers une nouvelle méthodologie de calibrage

Depuis 2011, une plateforme SAL (Synthetic Aperture Ladar) a été développée et testée en laboratoire à l’Institut National d’Optique (INO). L’INO souhaite maintenant évaluer la possibilité d’utiliser un tel système d’acquisition pour des applications réelles de cartographie urbaine, notamment de modélisation 3D intérieure. Actuellement, les balayeurs laser (i.e. LiDAR) sont couramment exploités pour réaliser de […]

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Development and characterization of elite Echinacea germplasm for natural health products and dietary supplements

Echinacea is a popular medicinal herb with a global market of ?$1 billion. While numerous Echinacea products are already available, variable plant chemistry and genetics leads to inconsistent product quality. In an effort to develop “chemically customized” varieties for herbal products and supplements, Amway Canada has partnered with researchers at the University of Ottawa and […]

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Improved Plastic to Oil Pyrolysis Process Technology with Advanced Plasma Technology

The field of plastic waste management is essential for sustainable society that utilizes plastic waste for energy production. Land filing and incineration of plastic waste has large environmental impacts due to GHG emissions. Thus, pyrolysis is considered a low environmental impact process with high value end products. RF thermal plasma technology will help reduce operating […]

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Accelerate development of new technologies and applications for advanced water treatment

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and treatment of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life from […]

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Accelerate development of new technologies and applications for advanced water treatment – Year two

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and treatment of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life from […]

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Validation of Off-gassing method and Development of Repeatability and Reproducibility of Data for the Iso-thermal Calorimetry (for ISO Standard development)

The key objective of this research is to validate the methodology for measurement of off-gassing from storage of wood pellets as well as development of data on heat generation from wood pellets. Canada is one of the main producer and exporter of wood pellets. 90% of this production belongs to British Columbia. Thus development of […]

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Effects of various compounds on central nervous system neurons as potential therapeutics against epilepsy

Xenon has developed isoform selective blockers of the sodium channels that are expressed in CNS neurons with the intent of developing them for therapeutic use, especially epilepsy. The primary goal of this research project is to determine the activity of compounds on CNS neurons. Until now, all characterization has been done with heterologously expressed channels. […]

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