Analyse du rôle et de l’impact des critères substituts dans l’homologation et le remboursement des médicaments anticancéreux au Canada.

Lorsqu’un nouveau traitement est évalué dans les études cliniques, des critères cliniques sont utilisés pour mesurer son efficacité en fonction de l’état du patient, notamment comment il se sent, fonctionne ou survit. Cependant, ces critères peuvent nécessiter un suivi prolongé avant de fournir des résultats concluants dans la recherche clinique en oncologie. Pour accélérer l’évaluation […]

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Plateforme intelligence pour la synthèse des connaissances environnementales et l’aide à la prise de décision

Face à la complexité croissante des enjeux environnementaux, l’entreprise T2 Environnement doit prendre des décisions rapides et éclairées à partir d’une grande quantité d’informations techniques, réglementaires et scientifiques. Ce projet vise à développer une plateforme intelligente capable de comprendre des enjeux posés en langage naturel et d’y répondre en s’appuyant sur les données internes de […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform – Year two

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Évaluation de l’utilité des mesures objectives et subjectives de la charge d’entrainement des artistes de cirque

La gestion de la santé physique et mentale des artistes de cirque est un défi, car les exigences varient beaucoup selon les disciplines de cirque. Actuellement, le suivi de la charge de travail, utilisé pour optimiser l’entraînement et prévenir les blessures dans d’autres sports, n’est pas encore appliqué aux arts du cirque. Ce projet vise […]

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Discussions environnementales et éco-anxiété: Vers l’atteinte d’une conscience environnementale

Le « avant pandémie » et le « après pandémie » divergent sur plusieurs aspects, dont la communication environnementale. D’ailleurs, depuis la pandémie, la population semble davantage fermée aux discussions climatiques, en plus de faire preuve d’éco-anxiété et démontrer moins d’efforts dédiés à la crise climatique. Toutefois, qu’elles sont les solutions viables pour la population […]

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newkid x Patricia: Stepping into the front doors as the new kid

newkid® is a creative company specializing in branding for startups that want to stand out. We establish and evolve brands to have a strong sense of self, clarity of purpose, distinctive style, and a singular perspective. Our work spans across brand strategy, creative direction, visual identity, naming, advertising, packaging, and digital experiences. The challenge: As […]

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AI/ML in Applied Marine Bioacoustics: Exploring the transfer of existing models from other domains

This project aims to answer the research question “can existing AI/ML models from other domains be applied to help address marine bioacoustics challenges?” One of the key challenges is that marine bioacoustics lags behind terrestrial bioacoustics in the level of research attention and technical advancement. Additionally, bioacoustics as a field has been slower in leveraging […]

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Analyzing process data alongside traditional item responses to obtain more accurate imputation, offering a deeper understanding of respondent behavior and enhancing the quality of imputing missing responses

This project aims to enhance proficiency estimation in large-scale assessments by improving missing-data imputation techniques. Specifically, the study focuses on refining Multiple Imputation with Denoising Autoencoders (MIDAS)—a deep learning-based approach—by incorporating item response time as an additional contextual feature. Unlike traditional item response theory (IRT) or regression-based methods, which rely on strong assumptions, the proposed […]

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