An integrated and adaptive study examining central and peripheral mechanisms of chronic pain in knee osteoarthritis patients

It has been estimated that 300 million people worldwide have osteoarthritis (OA) and this has increased by 97% over the past 25 years. The pain and loss of mobility experienced by people with knee OA can seriously reduce quality of life, while pain management causes significant healthcare spending. Unfortunately, the pain associated with OA is […]

Read More
Development of novel chemical probes and SARS-CoV-2 antiviral therapeutics through engineered HAI-2 protein inhibitors of TMPRSS proteases

Respiratory viruses exploit the biological activity of human proteins present at the surface of airway cells to allow viruses to penetrate that physical barrier and subsequently replicate in infected cells. It has been established that a family of human proteins, the type 2 transmembrane serine proteases, are directly responsible for this viral entry, but they […]

Read More
Machine learning applications to digital rock mechanics data

In rock engineering practice there is often insufficient time, schedule, and computational/expert resources to investigate complex rock mass phenomena in detail. The large amount of multivariate data that characterizes complex rock mass behaviour creates the ideal conditions to use machine learning. Machine learning allows for the use of all relevant data and can inform the […]

Read More
Comparing acute effects of natural and synthetically derived psilocybin using a mixed-methods approach

There is growing public interest in the therapeutic use of mushrooms that contain a psychoactive ingredient called psilocybin. There are two categories of psilocybin available for clinical use right now. Natural psilocybin, which is extracted from the mushroom, and synthetically derived psilocybin-like compounds. Synthetic psilocybin is more commonly used in clinical trials because companies producing […]

Read More
In Vivo Validation of a Wireless Fiber Photometry System

Fiber photometry is a powerful method for detecting neural activity or neurotransmitter release in specific brain cells. Doric lenses Inc., in collaboration with Benoit Gosselin’s lab, designed a lightweight, wireless optical recording prototype, which allows fiber photometry recordings in freely behaving animals without the constraints of tether. This new technology provides an innovative tool for […]

Read More
COSMIC – Functional Sizing of Quantum Software

Theoretically sound and industry-robust software measures are necessary to identify and select the most productive software development organizations (internal and external) and avoid significant overspending on software investments. Functional sizing measures, such as COSMIC Function Points – ISO 19761 – are necessary for the quantitative planning, monitoring, control, and objective assessment of software projects. Huge […]

Read More
Identifier les freins et leviers pour l’utilisation du génie végétal au Québec : une approche en géographie culturelle et sociale

Les techniques de génie végétal reposent sur l’utilisation de végétaux vivants pour différents usages, notamment la protection des cours d’eau contre l’érosion. Utilisées comme alternative au génie civil, elles offrent de nombreux bénéfices pour l’environnement (maintien ou restauration des habitats, corridor écologique, amélioration de la qualité physico-chimique de l’eau), et pour les sociétés (lutte contre […]

Read More
Characterization of PATL2’s role in Human Fertility for the Development of Non-hormonal Contraceptives

Norethindrone, the first oral contraceptive, is noted as one of the most pivotal molecules to be introduced into society. When introduced in 1960, norethindrone caused a societal paradigm shift by allowing for family planning and providing women with more agency over their reproductive system. Unsurprisingly, the women’s liberation movement, rise of feminism, and the increased […]

Read More
Developing an integrated hydrogen bio-methanation process to enhance and upgrade biogas production in an anaerobic digestion process

The increased energy prices and effects of climate change are severely impacting the day-to-day lives of Canadians. Moreover, essential sectors such as agriculture release substantial amounts of greenhouse gases, adding to climate change challenges. Hence, investing in local and sustainable energy sources is more critical now than ever to reduce these burdens. Therefore, biogas generation […]

Read More
Development of low-cost and lithium-metal stable halide solid electrolytes for high-performance all-solid-state batteries

Conventional Li-ion batteries using liquid electrolytes (LEs) are suffering from insufficient energy density and safety issues when used for the flourishing market of electric vehicles (EVs). Replacing LEs with solid-state electrolytes (SSEs) to fabricate all-solid-state lithium batteries (ASSLBs) has been regarded as an essential route to improve energy density and safety. Basically, a qualified SSE […]

Read More
Cortical changes measured with TMS and MEG following 3-weeks of hand movement training using a novel passive device

Stroke is the leading cause of adult disability, with long-term hand function impairments being the most common symptom among stroke survivors. As hand function plays a vital role in performing everyday activities, individuals with stroke face a significant impact in their quality of life including their ability to maintain independence, employment, and socially connectedness. To […]

Read More