Searching for Mushroom Extracts and Fractions with Potential Antidepressant Activity

Mental illnesses, particularly depression, are one of the leading causes of global disease burden. In addition to reducing the quality of life of patients and their relatives, they costs billions of dollars annually to the Canadian economy. Unfortunately, current antidepressant drugs are barely satisfactory and have numerous side-effects. The goal of this project is to […]

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Using a bottom-up approach to characterize the PEI agriculture sector within an energy system model of Atlantic Canada

The path to reaching net-zero emissions by 2050 in Atlantic Canada is both time- and resource-constrained. Energy system models can be used in this context to compare climate change mitigation options and to strategically plan for meeting climate change goals through cost-effective and timely means. Motivated by these circumstances, Net Zero Atlantic is building an […]

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Assessing the effect of CO2-induced degradation on wellbore integrity in CO2 storage reservoirs in Lloydminster

Carbon capture and storage (CCS) is essential in achieving the Paris Agreement’s objectives, reducing emissions and meeting Canada’s Net-Zero target by 2050. To this end, shallow depleted heavy oil reservoirs in Saskatchewan and Alberta provide a good opportunity for large scale CO2 sequestration projects. This research focuses on assessing the potential of CO2 storage in […]

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dCBT for Insomnia app

Tranq Sleep Care is focused on providing high-quality sleep care and creating new innovative solutions to diagnosing and treating sleep disorders. Tranq is currently developing an online web app that aims to help people suffering from insomnia. The challenge in delivering the treatment through an app is that it must be made such that patients […]

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Development of a tool for analysis of low-frequency oscillation modes in power systems signals

Power systems are subjected to randomly occurring normal and abnormal events that can trigger oscillatory response creating unsafe sustained fluctuations in power, voltages, currents and the frequency. Increasing integration of power electronics interfaced renewable generation contribute to new types of oscillations due to control interactions, sometimes supper imposed on classical electromechanical oscillations. Such oscillations can […]

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In vitro and in vivo evaluation of silicon-based quantum dot nanoparticles

Silicon quantum dots (SiQDs) are semiconductor nanoparticles with sizes ranging from 1 to 10 nm that show great promise for photonics, microelectronics, and fluorescent bio-imaging considering their ability to fluoresce from blue to near infrared light. In comparison to conventional quantum dots (which can release toxic metals), Si quantum dots are expected to be safer […]

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Impact of environmental factors on spontaneous reporting trends and safety signal detection in the EudraVigilance database

Changes brought to the ecosystem and geopolitical environment can have an effect on several fields including the healthcare system. Recently, we observed the impact that COVID-19 pandemic has had on the healthcare workers’ practices and people’s behaviour regarding their health status. Changes in spontaneous reporting trends were also observed. Lately, Europe has also witnessed the […]

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Screening DNA Methylation Signatures in Early Bovine In Vitro Embryos for Developmental Fitness

The success of assisted reproductive techniques (ART) in overcoming infertility or improving livestock genetic traits is undeniable. However, the use of ART in livestock has also been associated with an increased likelihood of certain anomalies (e.g., large offspring syndrome, musculoskeletal anomalies) and neonatal mortality because of suboptimal culture conditions. Our partner, L’Alliance Boviteq (Semex) has […]

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Non-Viral delivery of insulin and IL-10 to the intestine for immunotherapy for type 1 diabetes Year Two

There is increasing evidence suggesting a link exists between the gut immune system and several autoimmune diseases, including diabetes. The industrial partner of this project, enGene, has developed an effective non-viral based technology for the delivery of genes to the intestine. enGene has demonstrated the feasibility of delivering IL-10, which is an anti-inflammatory cytokine, to […]

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