Hyperpolarized 129Xe Cerebral Perfusion MRI Imaging Development

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

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Immunomodulatory fusion proteins to treat solid malignancies.

Immunotherapies are transforming conventional cancer treatments with significant improvement of patient survival rates. FDA-approved immunotherapies (immune checkpoint inhibitors, ICIs) have shown remarkable success in the treatment of hematologic malignancies but very low response rate in patients with solid tumors. Therefore, there is an urgent need for novel therapies against solid malignancies. Cura Therapeutics is developing […]

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Modelling Guidance for Low Impact Development Practices

To combat the degradation of receiving water resulting from stormwater runoff approaches that focus on retaining and infiltrating stormwater at the source, referred to as Low Impact Development (LID) practices, are being proposed more frequently in recent years. Toronto and Region Conservation Authority recently initiated monitoring of precipitation and runoff from a large industrial site, […]

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Development of a new generation of neurovascular device for the treatment of fusiform cerebral bifurcation aneurysms using CFD modeling and virtual simulation of stent crimping into a catheter

Cerebral aneurysm (CA), is an abnormal dilation of the cerebral arterial wall, which accounts for more than half a million deaths each year worldwide. Flow diverters (FDs) represent one method recently developed in treating CAs. Typically, they do not need coiling (releasing platinum micro-coils within the aneurysm) and act purely to prevent substantial blood inflow […]

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Development of a new generation of neurovascular device for the treatment of fusiform cerebral bifurcation aneurysms using CFD modeling and virtual simulation of stent crimping into a catheter – Year two

Cerebral aneurysm (CA), is an abnormal dilation of the cerebral arterial wall, which accounts for more than half a million deaths each year worldwide. Flow diverters (FDs) represent one method recently developed in treating CAs. Typically, they do not need coiling (releasing platinum micro-coils within the aneurysm) and act purely to prevent substantial blood inflow […]

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Evaluation of the implementation at scale of a public health intervention to promote social and emotional development in the early years in British Columbia

British Columbia’s Ministry of Mental Health and Addictions has identified healthy social and emotional development (SED) in early childhood as a priority action towards addressing the province’s mental health crisis. In response, ChildHealth BC (CHBC) is developing a multi-component provincial intervention to expand the capacity of caregivers to promote SED in young children- the first […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human Mammary Cells to Enable Their Optimized Growth as Organoids Ex Vivo

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human MammaryCells to Enable Their Optimized Growth as Organoids Ex Vivo – Year two

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Ensuring Stability and Accuracy of Multi-rate Electromagnetic Transient Simulation

Real-time digital power system simulators are used for testing and debugging control equipment intended for field installation. They simulate the power network in ‘real-time’, i.e., the simulation computations are rapidly completed so as to retain synchronism with a real-world clock. This requires the level of complexity in different components of the network to be judiciously […]

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Synthesis and modeling of stimuli-responsive polymers for fracturing fluids use

Currently, the global warming alerts, oil prices fluctuations and clean energy have paved the way of investing in the producing wells by enhancing the recovery of hydrocarbons compared to exploration wells. Applying hydraulic fracturing from injected fluids is most common method used. These fluids create cracks in the bedrock and push the hydrocarbons to the […]

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Segmentation automatique de dents à partir des scans oraux

L’automatisation des tâches de fabrication dans les laboratoires de prothèses dentaires revêt un intérêt considérable, à la fois pour les techniciens et pour les patients. En effet, une partie importante du travail consiste en des tâches répétitives, longues et qui exigent un effort de concentration et de minutie soutenu. Par conséquent, il existe une grande […]

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Research in Support of New Orthotropic Steel Bridge Deck Provisions for CSA S6:25

Orthotropic bridge deck is lightweight steel deck, typically fabricated by welding “ribs” to the underside of a flat steel plate. The potential benefits of these deck systems are compelling. For example, from 1991 to 1993, the deteriorating deck on the Champlain Bridge was replaced with orthotropic steel deck panels weighing 25% less than the original […]

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