Enabling next generation cardiac therapeutics with genetic engineering and novel in vivo models for cardiomyocyte transplantation – Year two

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to […]

Read More
Silicon Quantum Dot Trace Explosive Sensor

The rapid detection of high energy materials (i.e., explosives) and chemical, biological and radioactive (CBR) agents have received substantial attention because of its obvious importance to security and forensics. Applied Quantum Materials Inc. (AQM) is developing a straightforward luminescent quantum dot paper- and/or cloth-based detection system that shows instantaneous optical detection of nitro-based explosives in […]

Read More
Silicon Quantum Dot Trace Explosive Sensor – Year two

The rapid detection of high energy materials (i.e., explosives) and chemical, biological and radioactive (CBR) agents have received substantial attention because of its obvious importance to security and forensics. Applied Quantum Materials Inc. (AQM) is developing a straightforward luminescent quantum dot paper- and/or cloth-based detection system that shows instantaneous optical detection of nitro-based explosives in […]

Read More
Interaction between cannabinoid drugs and sodium channels in diabetes/high glucose induced oxidative stress, neuroinflammation, and neurotoxicity

Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes […]

Read More
Méthodologie de conception, vérification, et test des systèmes embarquéstolérants aux radiations

STAGIAIRE1 (PhD1, ISR) Génération et propagation des requis de conception vers le sous-système électronique embarqué. Les objectifs spécifiques du projet de l’étudiant PhD1 (tâches 1.1 et 1.2 du projet global) sont : 1) l’élaboration, la mise en oeuvre et la validation d’une stratégie permettant de déterminer la robustesse inhérente des autres éléments du système global, […]

Read More
Interaction between cannabinoid drugs and sodium channels in diabetes/high glucose induced oxidative stress, neuroinflammation, and neurotoxicity – Year two

Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes […]

Read More
Tracking the parasympathetic nervous system, emotions, and wellbeing in daily life.

Wearable body sensors are groundbreaking in that they allow for continuous and unobtrusive physiological measurements. The promise is that someday soon, smartphones will monitor our bodily state and thus prevent all kinds of wellbeing implications: acute physiological issues like stroke or heart attack; less acute but still serious illness, such as chronic illnesses caused by […]

Read More
Management and conservation of polar bears in Davis Strait: An integrated population modeling approach to estimating population size, growth rate and Total Allowable Harvest of a priority species in Nunavut, Canada.

Estimates of population size and structure of the Davis Strait polar bear population are uncertain due, in large part, to the prohibitive costs of conducting regular aerial surveys. In recent years, Inuit have indicated that increased bear abundance has resulted in public safety concerns. In addition, Inuit believe that polar bears have negatively impacted other […]

Read More
Management and conservation of polar bears in Davis Strait: An integrated population modeling approach to estimating population size, growth rate and Total Allowable Harvest of a priority species in Nunavut, Canada – Year two

Estimates of population size and structure of the Davis Strait polar bear population are uncertain due, in large part, to the prohibitive costs of conducting regular aerial surveys. In recent years, Inuit have indicated that increased bear abundance has resulted in public safety concerns. In addition, Inuit believe that polar bears have negatively impacted other […]

Read More
Validation of Novel, Tumor Microenvironment-based Targets for Biological Therapeutics

ImmunoBiochem is developing novel anti-cancer therapeutics to address unmet need in intractable solid tumors. Because solid tumors are highly heterogeneous and evasive, recognizing cancerous cells, while avoiding damage to normal tissue, is a challenge. As a result, many targeted therapies quickly come up against resistance, resulting in patient relapses. ImmunoBiochem is solving the issue of […]

Read More
Does the fetal short-term variability measure RMSSD reflect the fetal inflammatory status and can RMMSD be reliably recorded using a novel ultrasound fetal heart rate monitoring system

A certain number of newborn babies may suffer from infection. Many of such infections go unnoticed but may have negative effects on child’s health. There is currently no satisfying means to detect such babies early on. We have learned that using information contained in fetal heart beats we might better predict if a yet unborn […]

Read More