A PROPOSAL FOR CONTINUATION OF A RESEARCH PROGRAM TO INVESTIGATE THE ROLE OF CATHEPSIN K IN OSTEOARTHRITIS (OA) AND CREATE NEW DIAGNOSTIC ASSAYS FOR THE EARLY DETECTION OF OSTEOARTHRITIS

Osteoarthritis is a chronic painful disease of joints that involves the progressive destruction of the articular cartilage and bone and leads to pain. It affects both humans and animals. Animals can serve as models for the human disease and in this case we will study equine OA. There is currently no effective medication that can […]

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The Effects of Sex Differences on Acute Muscle Protein Synthesis Responses following High-Intensity Interval Training

Musculoskeletal conditions, such as sarcopenia and frailty, have been documented to affect over one billion individuals globally. To address the escalating issues of muscle atrophy, resistance training (RE) has been widely recognized for preserving and enhancing muscle mass. However, individuals nowadays often face time constraints, making it challenging to consistently engage in RE. Considering this, […]

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Determination of postharvest practices that impact the physicochemical properties cannabis biomass ash

This academic-industry collaboration aims to determine postharvest storage methods, combustion parameters and consumer behaviour for dried cannabis products that influence the physicochemical properties of cannabis ash, of which appearance (colour and integrity) has become an inadvertent dried cannabis product attribute that may drive consumer decisions towards legal distribution in a highly competitive market. Data generated […]

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Hepatic encephalopathy outpatient quality metrics

Hepatic encephalopathy is a major cause of morbidity and mortality. As an initial part of her thesis, the intern will contribute to determining priorities for the development of an outpatient cirrhosis database inclusive of hepatic encephalopathy quality measures. The findings will be disseminated through the intern’s thesis, peer-reviewed publications, and conference presentations, contributing to the […]

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Cytotoxicity analysis of novel monoclonal antibodies targeting SSAT-1

Cancer is one of the leading causes of death worldwide with approximately 8 million deaths in 2010. Most cancer treatments lack specificity and affect the whole body, with toxic effects on both cancerous and normal cells. The cytotoxic effect of a new therapy developed by Biomark Technologies, Inc. targeting cancer cells will be assessed. Biomark […]

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Simple Receptor Protein Generation

Receptor proteins are important for therapeutics, medicines, diagnostics and biomanufacturing. Generating new proteins is incredibly difficult however machine learning techniques have been developed to assist in evolving proteins. Using these techniques, I plan to create receptor mimics that are smaller and have improved properties. These will benefit many industries such as therapeutics, medicines, diagnostics and […]

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Validating chemical candidates for axon regeneration in the rodent visual system

Neurons are like electrical wires that help the brain communicate with itself and other parts of the body. If broken, this ability is impaired, leading to reduced sensation and or motor function. Neurons in the mature mammalian central nervous system (CNS) don’t grow back after injury due to cellular, biochemical and physical barriers. Currently, there […]

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Uncovering genetic interactions of the translesion synthesis pathway: targeting DNA repair mechanisms as a therapeutic strategy in cancer

This project investigates how different genes involved in DNA repair work together to keep cancer cells alive. We’re focusing on a specific process called translesion synthesis (TLS), which helps cells bypass damage in their DNA. By understanding these genetic interactions, we hope to identify new ways to target and kill cancer cells, especially those that […]

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Application of engineering grade vector flow ultrasound in human physiological study

This project will stimulate discovery into blood flow dynamics and strengthen ties between Canada and Japan. By learning advanced techniques from Japan’s cutting-edge Verasonics ultrasound system, the intern will study large veins and the heart during physiological stressors including body tilting, breathing maneuvers and exercise. The potential discoveries may help uncover diagnostic imaging capabilities to […]

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Implantation d’une bibliothèque numérique d’apprentissage pour soutenir la trajectoire d’apprentissage des patients hospitalisés dans la trajectoire de récupération améliorée après la chirurgie : Étude pilote d’acceptabilité, de faisabilité et d’effets préliminaires

L’enseignement auprès des patients est un aspect crucial à la trajectoire de récupération améliorée après la chirurgie (RAAC). L’environnement numérique d’apprentissage (ENA), incluant un espace de suivi des apprentissages en ligne, représente un outil utile pour assurer un transfert d’informations plus spécifique et pédagogique. Ce projet vise à explorer l’acceptabilité, la faisabilité et les effets […]

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Design and screen novel cell-penetrating peptides intracellular delivery of proteins

This project focuses on improving the delivery of a therapeutic protein called ribonuclease (RNP) into cells, which could help treat certain genetic diseases. The challenge with current delivery methods is that the proteins often have trouble getting inside the cell and reaching the nucleus, where they are most needed. To address this, Sinedore Bioscience, in […]

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