Informing clinical practice and pandemic preparedness at The Hospital for Sick Children using the POPCORN COVID-19 database

The COVID-19 pandemic presented unique challenges in the provision of optimal patient care, including at The Hospital for Sick Children (SickKids). For instance, there was a lack of evidence regarding appropriate viral testing and interventions, and the virus was also associated with adverse health events occurring well beyond acute infection. In response, SickKids has been […]

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Levels and Patterns of Physical Activity and Sleep in people with COMISA Versus Age- and Sex-Matched Insomniacs and Good Sleepers

Obstructive sleep apnea (OSA) and chronic insomnia have each been associated with decreased levels of physical activity (PA). In turn, insufficient PA can lead to poorer sleep. For people with both OSA and insomnia – a combination called COMISA – guidelines recommend continuous positive airway pressure (CPAP) for OSA and cognitive behavioural therapy for insomnia […]

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Functional correlates of central disorders of hypersomnia: a global multi-cohort analysis

The proposed project aims to identify functional brain differences between people with different types of central disorders of hypersomnolence (narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia) By combining data from over 1,800 participants from research sites across 21 countries, the project will reveal key brain differences that enhance our understanding of the underlying […]

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Development of an online rapid cognitive-motor assessment tool to monitor brain health.

This project aims to maximize the accessibility of an existing validated computer tablet-based brain health assessment tool. Specifically, we wish to expand the assessment tool to a web-based platform and improve its ability to rate a user’s performance in a personalized way. Currently, there are few choices for clinicians to test rule-based skilled performance needed […]

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On-demand nanozyme system for rapid eradication of multidrug-resistant biofilms

Chronic wounds pose a significant threat to public health. The economic burden of wounds is projected to increase to $18.7 billion by 2027, with an annual growth rate of 6.6% from 2020 to 2027. By providing a fertile ground for the growth of infectious microorganisms, especially in immunocompromised patients, wounds lead to extended hospitalization and […]

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Continuous, Directed Evolution of Human Opioid Receptors in Yeast

Cell-based biosensors are living cells that have been genetically engineered to detect and measure different chemicals of interest. Similar to the cells in our nose that allow us to smell isoamyl-alcohol (banana), or allyl thiol (garlic), biosensors use protein receptors and produce a measurable read-out such as fluorescence to determine the amount of target molecule […]

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Evaluation of a new program for mental health patients in the emergency department

NYGH has opened a new mental health and addiction-focused area in its emergency department. Part of the development of this new area includes integrating staff from community-based organizations to better connect patients with outpatient treatment services as well as other health and social supports they may need. The practicum will involve developing an understanding of […]

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Implémentation de la Stimulation Électrique Fonctionnelle sur les membres supérieurs

Ce projet vise à améliorer la réadaptation des personnes atteintes de paralysies ou de troubles neuromusculaires affectant les bras, grâce à une technologie appelée stimulation électrique fonctionnelle (SEF). Cette technique utilise des impulsions électriques pour activer les muscles, permettant des mouvements que les patients ne peuvent pas réaliser seuls. L’étude se concentre sur l’effet de […]

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Nature-derived solutions: Development of a West African herb-derived compound for tackling infections

More than 25 million Africans and 800,000 Canadians suffer from chronic wounds. Wound infections are a leading cause of hospitalization and disability in immunocompromised people and vulnerable populations. This is compounded by the indiscriminate use of antibiotics, leading to antimicrobial resistance and failure of treatments. Therefore, antibiotic alternatives are needed. Inspired by traditional wisdom, phytotherapy […]

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Development and Validation of a Deep Learning-Based Infrared Thermography Model for Detection and Differentiation of Thyroid Nodules

Patients referred for thyroid nodule (TN) assessment will be invited to participate in the study. Patients will undergo screening using infrared thermography (IT) and ultrasound (US) with needle insertion. Neck IT thermograms will be captured using the FLIR TS865 for all patients’ frontal and lateral norms. With the IT camera software, the regions of interest […]

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Elucidating the role of the peripheral-brain immune axis in Parkinson’s disease

Parkinson’s disease is commonly described as a brain disorder, but recent research suggests that early events outside the brain (periphery) may influence Parkinson’s disease neuropathology. The blood-brain barrier is a structure that protects the vulnerable brain tissue from blood-borne toxins and circulating immune cells, but barrier function appears compromised in PD. A consequence, there may […]

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