CAR T-cell therapy is a type of immunotherapy that displays remarkable potential to treat B-cell cancers. In this treatment, a protein on the surface of B-cells called CD19 is targeted, allowing for the specific killing of B-cells in patients. However, CD19 is a “difficult to express” protein, characterized by high levels of aggregated protein and […]

This project aims to develop a new clinical scoring system to help veterinarians and cat owners identify early signs of age-related cognitive decline in domestic cats. The study combines a questionnaire-based measure of behaviour and cognitive function with a full veterinary health check and experimental cognitive assessment tasks to accurately identify subtle changes in behaviour, […]

Le “digital free tourism” (tourisme déconnecté ou déconnexion numérique en milieu touristique) désigne une forme de tourisme où les personnes voyageuses peuvent se déconnecter des technologies numériques (téléphones intelligents, médias sociaux, etc.) pendant leur séjour. Certains travaux récents questionnent cependant les limites du tourisme déconnecté, en soulignant par exemple le stress vécu à la suite […]

Reliable annotations set critical ground truths for modern data science initiatives. In life sciences, however, large volumes of physiologic data streams produce computational bottlenecks that hinder this workflow. A researcher’s only viable alternative is to adopt a DIY approach, exporting data to separate coding environments. This fragments the analysis from the visual context and corrodes […]

This project will help develop GutSight, a new test to monitor inflammation in people with inflammatory bowel disease (IBD) without relying only on colonoscopies. Over four months, I will improve the way we measure gut biomarkers, strengthen the computer model that predicts disease activity using data from 400 patients, and do basic research on how […]

This project will explore how eye movements can be used to improve assistive Augmented Reality (AR) devices for people with motor impairments. Many AR systems rely on head, hand, or body movements to make choices, but this is not always possible for individuals with limited mobility. However, eye movement is often preserved, making it a […]

This project aims to uncover how Cfp1 PHD domain, a chromatin reader domain traditionally known for coordinating zinc might use a special iron–sulfur (Fe–S) cluster to sense and respond to changes in the cell’s environment. By studying this protein under oxygen-free conditions and determining its 3D structure, we hope to reveal how redox chemistry influences […]

L’activité physique joue un rôle essentiel dans l’équilibre entre l’énergie que nous mangeons et celle que nous dépensons. Pourtant, lorsqu’on devient inactif (blessure, hospitalisation ou simplement un mode de vie sédentaire), cet équilibre se dérègle. Nos besoins énergétiques diminuent, mais notre appétit ne s’ajuste pas toujours : nous continuons souvent à manger comme si nous […]

Ce projet de recherche vise à mieux comprendre une bactérie appelée Enterococcus cecorum, qui cause des infections graves chez les poulets de chair. Depuis quelques années, cette bactérie est devenue l’un des principaux problèmes de santé dans les élevages avicoles, entraînant boiteries, mortalité et pertes économiques importantes pour les producteurs. Les chercheurs vont analyser les […]

In Canada and worldwide, health systems are facing tremendous capacity pressures with aging populations putting increasing demands on health services. Caregivers play a vital role in supporting older adults at home. Caregivers often experience distress and burnout and need help navigating the health system. The overall goal of the project is to evaluate the feasibility […]

The proposed Research Plan is to evaluate the active targeting effect of glycan ligands for the delivery of conjugated lipid nanoparticles (LNPs) to human bone marrow CD34 + hematopoietic stem and pluripotent cells (HSPCs) and human peripheral blood mononuclear cells (PBMCs) such as T cells and B cells. A reporter mRNA will be formulated into […]

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Its metastatic form (mRCC) remains incurable and resistant to chemotherapy and radiation. Current treatments targeting the tumor microenvironment offer limited benefit, highlighting the need for new strategies based on disease biology. ccRCC is difficult to target due to its cellular heterogeneity […]