Quelle approche structurée et quel outil centralisé peuvent être développés pour structurer et rassembler l’analyse des changements postapprobation, afin d’optimiser l’efficience du processus d’évaluation de leur impact réglementaire et d’assurer leur conformité à l’international dans une entreprise pharmaceutique globale ? Le projet permettra de structurer et de centraliser l’analyse des changements post-approbation afin d’assurer leur […]

Peripheral T-cell lymphoma (PTCL) is a type of blood cancer with poor treatment outcomes, as patients often relapse or do not respond to available therapies. A key factor driving the growth of cancerous T cells in PTCL is a protein called ITK, which helps these cells survive by activating biological pathways that boost cell growth […]

Huntington’s Disease (HD) is a debilitating neurodegenerative disease marked by progressive loss of motor control and cognitive function. Presently, there are no disease-modifying therapies. A potential avenue for slowing or stopping HD progression is to target huntingtin (HTT), or polyglutamine-expanded mutant HTT (mHTT), for degradation using proteasome targeting chimera (PROTAC) technology. A PROTAC will bring […]

Cardiac conduction disturbances (CDs) are a prevalent complication of transcatheter aortic valve implantation (TAVI) procedures, which are performed by interventional cardiologists to treat heavily calcified aortic valves. CDs may emerge during or after TAVI, and are typically caused by mechanical injury to the heart’s conduction system, which can be highly challenging to prevent during the […]

Gingival recession affects ~50% of the population and results in the exposure of tooth root surfaces, which leads to an increased risk of dental caries. The gold standard treatment is autologous grafts involving tissue being harvested from the roof of a patient’s mouth, leading to pain and bleeding, the inability to eat, risk of infection, […]

La prématurité constitue un réel problème de santé publique mondiale car approximativement 13,4 millions de nouveau-nés par an naissent dans cet état dans le monde, déterminant ainsi un taux de prématurité estimé à 11%. Cependant, la grande part de ces naissances revient aux pays en voie de développement, avec plus de 43% des cas. Bien […]

This initiative aims to directly apply cutting-edge health research to improve care in long-term and assisted living facilities, bridging the gap between academic insights and practical healthcare delivery. Through a focused two-year project, facilitated by a Mitacs Business Strategy internship, we will embed a specialist intern to translate research findings into actionable improvements within these […]

Persistent organic pollutants (POPs) are harmful chemicals that threaten marine life and ecosystems worldwide, including majestic creatures like killer whales (Orcinus orca). Despite efforts like the Stockholm Convention treaty to control these pollutants, they persist in the environment and continue to harm wildlife. Killer whales, as top predators, face particular risks due to their position […]

Les écosystèmes côtiers rendent des services écosystémiques importants dont la séquestration du carbone pour la lutte contre les changements climatiques. Dans le contexte de l’élévation du niveau marin, ces écosystèmes sont vulnérabilisés à la suite d’importantes pertes de superficies avec le recul des côtes. Le littoral de la côte du Golfe du Saint-Laurent vers la […]

Although zooplankton monitoring is crucial for informed conservation, data on nearshore zooplankton ecology, despite its importance for forage fish, is lacking. This study will use ZooScan image analysis to process samples collected by the Pacific Salmon Foundation Citizen Science Oceanography program in Malaspina Strait (2015 – ongoing) and assess the seasonal dynamics of the nearshore […]

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Malgré les normes les plus strictes, la viande de volailles se retrouve en tête de liste comme source d’exposition des consommateurs à des bactéries pathogènes zoonotiques responsables de toxi-infections alimentaires au Canada, où chaque année plus de 4 millions de cas d’infection sont déclarés aux autorités de santé publique. Clostridium perfringens entérotoxinogène figure parmi les […]