Assessment of Salmonella enterica and Campylobacter jejuni inhibition using lead single domain antibodies in combination with dysregulators of the master protease ClpP

The human pathogenic bacteria Salmonella enterica and Campylobacter jejuni are commonly found in the intestine of poultry. Consumption of infected chicken and eggs, and its derivatives, is the main and most important source of infection outbreaks in humans causing diarrhoea, fevers and abdominal cramps. In some cases, severe diarrhea and dehydration followed by systemic spreading […]

Read More
Toxicopathological Determination of Safe Dose Ranges of Neonicotinoids for Honey Bee Colonies

The ‘gold standard’ mammalian safety toxicopathological tests are very sensitive and reproducible examinations used by veterinary pathologists in the pharmaceutical industry and regulatory agencies to detect sublethal toxic effects of candidate drugs, pesticides and other chemicals in laboratory animals to determine the safe dose range of these medications/chemicals for humans and animals. However, comparable toxicopathological […]

Read More
Évaluation de l’impact de l’aménagement forestier sur les paysages forestiers de la Mauricie et de leur susceptibilité aux défoliations par la tordeuse de bourgeons de l’épinette (TBE)

Le dévoilement des plus récent résultats du calcul des possibilités forestières réalisé par le Bureau du Forestier en Chef a permis de constater une augmentation importante des volumes de bois sur pied des essences résineuses sur le territoire de la Mauricie. Ce constat pourrait remettre en question certains des objectifs rattachés aux enjeux écologiques identifiés […]

Read More
Optimizing Movement in Children Study (OMiCS)

OMiCS represents a broad research initiative exploring the relationship between physical literacy (PL) in children and markers of biological health. The research seeks to expand on the literature surrounding the components of PL: physical competence, confidence, and motivation for being active, and determine whether any of these components can shift objective biomarkers of health (the […]

Read More
Développement d’emballages bioactifs à partir d’extraits forestiers

Les plantes sont riches en composés naturels ayant des propriétés antioxydantes et antimicrobiennes. Ces composés sont souvent des composés phénoliques ou des terpènes. Plusieurs études ont montré l’effet antimicrobien d’extraits d’épices et de fruits. Cependant aucune étude n’a permis à ce jour de caractériser l’écorce de bois. L’écorce de bois est un sous-produit des produits […]

Read More
Validation of the educational impact of a holographic lecture

UBC and Microsoft intend to collaborate on an applied research project where 3D models of the brain will be used to create an interactive Holographic lecture using Microsoft’s new augmented reality device, the HoloLens. The will form the basis for a lesson or “HoloLecture,” and will feature new interactions to take advantage of the HoloLens’s […]

Read More
Increasing Patient Engagement and Informing Marketing Decisions through the use of Patient Personas and Patient Journey Mapping

Mobile health (mHealth) apps allow patients to practice self-care and manage their chronic diseases. Common functions in mHealth tools allow users to monitor their symptoms and mood, keep a thought diary, track medication use and trend information; this provides data that can be used to better understand patient behaviour to ensure that patient needs are […]

Read More
Mécanismes sous-jacents à la performance du naissain de moule du bassin du Havre-Aubert, aux Îles-de-la-Madeleine

Aux Îles-de-la-Madeleine (Qc), les mytiliculteurs s’approvisionnent en jeunes moules (naissain) dans une petite lagune (Bassin du Havre-Aubert, BHA) dont les stocks récoltés (captage) présentent une résistance particulière, du fait de leur importante diversité génétique. Toutefois, l’espace disponible pour les activités maricoles y est limité et le rendement de captage est variable d’une année à l’autre. […]

Read More
Validation of an innovative industrial process for the pre-treatment of hay in controlling inflammation and respiratory obstruction associated with Severe Equine Asthma (SEA)

Severe Equine Asthma (or “heaves”) is the most common respiratory disorder affecting horses in stables, and impacts an estimated ~15% of the equine population in the northern hemisphere. Heaves is a chronic condition for which there is currently no cure, and its symptoms are quite dramatic causing severe breathing difficulty for affected horses, making it […]

Read More
Interaction of Cyclin-dependent kinase 2 with CR6-interacting factor 1, and the inhibitor search for such interaction against leukemia treatment resistance

Cyclin-dependent kinase-2 (CDK2) regulates cell cycle, whose structure and biological characteristics are well known. CRIF1 plays a regulatory role in the bone marrow microenvironment-induced leukemia cell cycle arrest through inhibiting CDK2. In this multi-disciplinary research, we will use a combined structure function study to reveal the interaction between CDK2 and CRIF1. This will facilitate the […]

Read More
Analysis of TGF-? traps as effective immunostimulating cancer treatments

AVID200 is a TGF-? trap that specifically sequesters TGF-?I and TGF-?III to enhance antitumour immunity to inhibit tumor growth. AVID200 also avoids adverse side effect of depleted of TGF-?II. AVID200 is relatively short-lived in circulation, decreasing its capacity to exert desirable enhancement of anti-tumour immunity. To increase the effectiveness of TGF-? traps, a panel of […]

Read More