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I have recently developed a piece of software that can be used to interpret the effects of DNA sequence differences in human genomes. The analysis produces results that predict disease mutations. Dr. Rogan’s laboratory has developed approaches of visualizing DNA sequence data, which I will incorporate into this software. I will modify the existing visualization […]

Feather pecking (FP) in egg-laying hens, where individuals peck repetitively and excessively at other birds to pull out and eat their feathers, is a challenge for the industry with large economic and welfare implications. High prevalence of FP is reported (60-80%) and this is associated with mortality rates of up to 20-40%, which translates to […]

Feather pecking (FP) in egg-laying hens, where individuals peck at other birds to pull out and eat their feathers, is a challenge for the sector with large economic and welfare implications. It is especially of concern in systems where birds are housed in large social groups as it is harder to control. With new policies […]

Common scab is a world-wide potato disease that is responsible for important economic losses. The control of the disease is difficult and soil fumigation is often the only approach available. In Atlantic Canada, crop losses associated with common scab are economically important and the disease has been progressing in severity. Therefore, Dr. Filion, in association […]

Patients with posttraumatic stress disorder (PTSD) are characterized by decreased prefrontal cortex (PFC) regulation on hyperactive emotion generation regions, such as the amygdala. Real-time (rt)-fMRI neurofeedback allows for localized brain regions to be self-regulated through neuroimaging signal feedback. Recently within our lab, learning to decrease amygdala activation via neurofeedback was shown to normalize the neural […]

Patients with posttraumatic stress disorder (PTSD) are characterized by decreased prefrontal cortex (PFC) regulation on hyperactive emotion generation regions, such as the amygdala. Real-time (rt)-fMRI neurofeedback allows for localized brain regions to be self-regulated through neuroimaging signal feedback. Recently within our lab, learning to decrease amygdala activation via neurofeedback was shown to normalize the neural […]

Wildland fire fighting is a physically demanding public safety occupation. Front-line wildland fire fighters (WFF) must have an appropriate level of job-related fitness for safe and efficient work performance. Beginning in 2011, it was required that all WFF must demonstrate that they are capable of meeting the rigorous physical demands encountered during an initial attack […]

The analysis of protein-protein interactions is critical for understanding cell growth control, and how aberrant connections contribute to cancer and other diseases. Mass spectrometry is a critical tool in this field, but sample complexity, instrument dynamic range and resolution limit some applications. This project will evaluate the use of the SelexION ion mobility device and […]

The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a […]

By studying protein complexes, scientists gain insight into how cells are regulated and how aberrations in protein-protein interactions cause disease. Mass spectrometry is a technology that allows proteins to be identified and quantified in a systematic and unbiased manner. New technologies from mass spectrometer vendor SCIEX aim to improve the throughput, accuracy and reproducibility of […]

Memory impairment is the most common cognitive complaint among older adults. On the other side of the developmental spectrum, young adults that have been diagnosed with Autism Spectrum Disorders (ASD) have difficulty adapting flexibly to changing social circumstances. These memory and social deficits disrupt every day living. At present, promising interventions based on research using […]