Engineered genetic traceability solution for commercerical ale yeasts and methodology for rapid dectection and identification of diastatic yeast contamination in beer fermentation

This project will demonstrate that one or more unique DNA ID sequences (“DUID”) can be inserted into the genomes of select strains of Saccharomyces cerevisiae ale yeast and S. cerevisiae var diastaticus yeast strains without affecting the heritable traits of the host and then the DUID can be recalled upstream in the brewing process. By […]

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Using adaptive management to reduce fishing pressure on Golden Cod near the Gilbert Bay Marine Protected Area (MPA)

Despite protection measures, the Golden cod sub-population in the Gilbert Bay Marine Protected Area is experiencing steep decline. Given the regulatory complexity and reluctance of industry to consider a split or delayed season for surrounding fisheries, partners aim to create an alternative solution to balance economic fishing interests with conservation objectives. The goal of this […]

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Development of a Proof of Concept for a System to Increase Success Rates of Organ Transplant and Donation Matches

Transplantation is the preferred treatment for patients whose kidneys have failed. There is an ever-growing gap between patients in need for a transplant and available donors. In response to this need, there has been an increase transplantation of donors who experienced circulatory determined death (DCD). However, many potential DCD donors fail to end up in […]

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Validation of Novel, Tumor Microenvironment-targetedImmunomodulatory Biological Therapeutic

ImmunoBiochem is developing novel anti-cancer therapeutics to address unmet need in intractable solid tumors. Because solid tumors are highly heterogeneous and evasive, recognizing cancerous cells, while avoiding damage to normal tissue, is a challenge. As a result, many targeted therapies quickly come up against resistance, resulting in patient relapses. ImmunoBiochem is solving the issue of […]

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Screening of bacteriophage receptor on mutant bacterial libraries

Phagelux has developed a cocktail of bacteriophages (bacterial viruses) that treat infections with bacteria resistant to antibiotics. During the curse of treatment, bacteria may become resistant to bacteriophages included in the cocktail. This project aims at determing the bacteria surface markers on which bacteriophages can bind and start their therapeutic function. This will help Phagelux […]

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Applicability and Utility of the PHEMI Secure Clinical and Multiomics Platform for Precision Medicine

Advanced prostate cancer (PCa) manifests as metastasis and metastasis is the leading cause of death for PCa patients. The underlying mechanisms remain poorly understood. We hypothesize germline variants may modulate a tumor’s propensity for metastasis. If validated a saliva or blood based test could be developed to predict risk of metastasis. Our objectives are: (1) […]

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Thousand Protein Multiplexed Mass Spectrometry Assay for Biomarker Discovery

In recent years, the interest given to disease biomarkers has boomed. Biotechnology and pharmaceutical companies are exploring ways to use biomarkers to speed up the drug development process, as well as to rapidly assess a diseases state, staging, progression and response to therapy. Multiple reaction monitoring (MRM) Mass Spectrometry (MS) has been shown to be […]

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Rapid Implementation of a Shared COVID-19 Tracking and Response Platform for First Nations, Inuit, and Métis Populations in Canada

As COVID-19 rapidly spreads across Canada, the morbidity and mortality rates are likely to follow the same patterns as H1N1, and be significantly higher in First Nation, Inuit and Métis (FNIM) populations compared to non-Indigenous Canadians. Thus, there exists an urgent and currently unmet need to track and respond to incidences of COVID-19 in these […]

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Measuring the contributions of non-crop areas to precision canola yield: Phase 2

Canola growers recognize that the beneficial arthropods that live in natural habitats and non-crop areas may play an important role in augmenting and stabilizing crop yields. These bees, flies, beetles, spiders and other arthropods may spill over into the crop, and through pollination or pest control, help to improve yields, decrease inputs, and increase profitability. […]

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Antioxidant Properties of Indigenous Plant Species of Newfoundland and Labrador

This research aims at study antioxidant properties of berry plant species native to Newfoundland and Labrador. Antioxidants are compounds which are required to alleviate the harmful effects of free radicals. If the level of free radicals is high in body, they can damage proteins, lipids, DNA, and other biochemicals in our body. Skin is prone […]

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