In Vitro Screening and Validation of Phyto-Cannabinoids in Glaucoma

Glaucoma is the second leading cause of blindness in the world, mainly induced by increased pressure in the eye. Marijuana has been shown to reduce such pressure, thus benefit glaucoma patients. In this project, we test several components from marijuana extracts that are unlikely to cause psychoactive symptoms, for their therapeutic effects on glaucoma. This […]

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Caractérisation du rôle de la protéine précoce immédiate 1 dans l’intégration chromosomique des herpèsvirus humains de type 6A/B

L’herpèsvirus humain 6B (HHV-6B), virus de la roséole, infecte près de 95% de la population avant l’âge de deux ans. Il est connu qu’HHV-6B intègre son matériel génétique aux télomères de la cellule qu’il infecte, régions des chromosomes qui contrôlent la durée de vie des cellules. Il est anticipé qu’une insertion d’HHV-6B à cet endroit […]

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Mechanisms of the relationship between ageing and dementia.

As our population ages, the burden of dementia is growing. Alzheimer’s disease (AD) is the most common cause of dementia; currently we do not have any disease-modifying treatments for AD. There is motivation to better understand the mechanisms of AD development and expression to control the burden of disease. Frailty is related to neuropathological features […]

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Elaboration of a Phase II clinical study protocol for the treatment of metastatic non-small cell lung cancer (NSCLC) using AB-16B5, an epithelial to mesenchymal transition (EMT) inhibitor, in combination with docetaxel

The molecular mechanisms responsible for the occurrence of metastatic cancer are beginning to be elucidated with the identification of key regulators. Increasing evidence points to tumor cell epithelial to mesenchymal transition (EMT) as an important contributing process to metastatic evolution. The identification of factors that are stimulated during EMT might provide the means to develop […]

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Investigating Ca2+ signaling in plants using genetically encoded Ca2+ sensors

Ca2+ is a very important signaling molecules for animals and plants alike. Ca2+ signaling has been heavily studied in animals but relatively less is understood in plants. Cyclic Nucleotide Gated Ion Channels (CNGCs) are important channels that are thought to be important in regulating Ca2+ homeostasis under different conditions in plants. The goal of this […]

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Development of a novel Saccharomyces yeast RNAi production and delivery platform

Heavy pesticide and antibiotic use are prevalent in modern agriculture and is an essential requirement to feed the ever-increasing human population. Their increased use, however, has also resulted in a loss of ecological biodiversity, environmental contamination, emerging pesticide/antibiotic resistance and is an economic burden to farmers, especially in low income nations. The research proposed aims […]

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Identifying microRNA expression profiles and biomarkers in peripheral whole blood in patients with chronic obstructive pulmonary disease

Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in Canada and may affect up to as many as 3 million Canadians. However, due to inadequate diagnostic tools, 50% remain undiagnosed. Furthermore, COPD patients also suffer attacks, or exacerbations, which can hospitalise the patient, worsen their condition and take weeks to recover […]

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Investigating the Effect of Ironwood Clay on Skin Fibroblasts and Immune Cells

Clay has been extensively in use around the world for cosmetic and medicinal purposes. becoming increasingly popular as a rediscovered treatment for many different health and skincare conditions. Clays contain massive amounts of trace minerals, necessary for good health. This may explain many of the healing properties of clay. Ironwood Clay and its Glacial Oceanic […]

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Dual eye tracking for assessment of team cognition

Current assessment tools for teamwork are based on subjective assessment forms in general, objectively assess teamwork is a challenging task in the operating room. Laparoscopic surgery is a type of surgery that requires the surgeon and assistant to work cohesively, since the surgeon’s view is provided by the assistant consistently maneuvering the camera. We used […]

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