Des fermentations in vitro dans des bioréacteurs seront réalisées après optimisation des paramètres (pH, temps de résidence…) grâce aux données collectées dans la littérature sur les caractéristiques du syndrome de l’intestin irritable. Les fermenteurs seront inoculés avec du microbiote fécal provenant de sujets présentant un syndrome du côlon irritable (3 répétitions avec selles de 3 […]

Recent scientific breakthroughs have led to the development of methods to differentiate human PSCs (hPSCs) into skeletal muscle cells. This has allowed, for the first time, the development of cellular models to study muscle diseases such as Duchenne Muscular Dystrophy and the possibility to utilize these cells for cell therapy applications. However, the reliability, efficiency […]

In this project, we partner with Multi-Magnetics Inc. to develop improved approaches to make heart images acquired with simultaneous MRI and Positron Emission Tomography (PET) images of the heart more accurate. This includes compensating for the effect of custom image acquisition hardware (coils) that are present in the scanner at the same time as the […]

There is a growing need for the development of guidelines related to best practices in the treatment of chronic disease. Clinical practice guidelines have become an important means of translating scientific evidence, identifying gaps in the literature, distributing new knowledge, and improving patient care. Following a teleconference, and an in-person meeting between national and international […]

It remains unclear which factors drives variation in the gut microbiome across humans. Past work has taken an evolutionary perspective and compared the gut microbiome of humans on Western diets to wild primates and humans on non-Western diets and identified particular microbes which are at different abundances. However, the focus of these studies has mainly […]

The intention of this project is inquiry into the role of force signaling in skeletal muscle repair. Before muscle damage, muscle stems cells that are yet to be incorporated in the muscle fibers are relatively inactive, but when injury occurs they can multiply and are recruited to the site of damage. Many aspects of the […]

Alzheimer’s disease (AD) is the most common neurodegenerative disorder. SignalChem LifeSciences Corp. recently developed a potent small molecule inhibitor (SLC-0149) for targeting CAIX, a hypoxia inducible gene, in the application of treating cancers. Since hypoxia has been implicated as a factor to facilitate AD development, this study aims to explore the potentiality of applying SLC-0149 […]

Pesticide application in crops has been considered a potential cause of bat population declines in Europe. However, no research on this topic has been conducted in tropical agrosystems, where the use of pesticides is extensive and bat diversity is higher. Considering that insectivorous bats can eat more than 90% of their body mass every night, […]

The most promising strategy to reduce texturizing ingredients is the incorporation of bacterial cultures that have intrinsic capacity to modulate the texture of fermented milk due to the production of exopolysaccharides (EPS). Yoplait has sequenced the genomes of several bacteria strains that could be introduced as starters or adjunct cultures in yogurt. The main objective […]

Diseases and injuries can affect essential activities of daily living like holding objects or walking. Investigating ways to optimize motor learning and performance is important for patient (i.e., stroke patients) and healthy populations (i.e., athletes). Exercising muscles to fatigue on one side of the body may improve motor tasks executed by the opposite limb. This […]

The heart beats 3-4 billion times in a person’s lifetime, making it the only part of the body that continues to work – without a break – for one’s entire existence! For this to occur, the heart must be highly regulated, so that is continues to function normally. Much of this regulation occurs within the […]

La scoliose idiopathique de l’adolescent (SIA) est une maladie de cause inconnue, affectant 4% de la population pédiatrique et qui implique une croissance anormale et désynchronisé de la colonne vertébrale. Notre laboratoire s’intéresse à la composition de la flore intestinale (appelée microbiote) pour tenter d’expliquer le développement et la progression de la SIA. Dans ce […]