Development of new therapeutics for castration-resistant prostate cancer treatment

Castration-resistant prostate cancer is a late stage disease and many people die of it due to lack of effective therapeutic drugs. In the current project, we propose to develop new therapeutic drug a to specifically target CRPC’s common weak points, which are MCT4 and eIF4E gene’s proteint products that play very important roles in regulation […]

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Bioactive peptides and joint inflammatory response after in vitro human digestion of collagen hydrolysate

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol® Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following digestion, hydrolyzed collagen yields amino acids and peptides that can lead to the health promoting properties of the supplement. However, the specific identity and mechanisms of action of […]

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Lifestyle and cognition: a large-scale approach

Online cognitive testing provides unprecedented opportunities for exploring human brain function among the general population. Cambridge Brain Sciences Inc has created an online cognitive testing platform that has attracted more than 1.5M users and has hosted more than 300 studies of cognition. I plan to leverage their unique dataset to explore the interrelationship between demographic […]

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Lifestyle and cognition: a large-scale approach – Year two

Online cognitive testing provides unprecedented opportunities for exploring human brain function among the general population. Cambridge Brain Sciences Inc has created an online cognitive testing platform that has attracted more than 1.5M users and has hosted more than 300 studies of cognition. This research plans leverage their unique dataset to explore the interrelationship between demographic […]

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A comparison of finite element model-predicted brainstem strains between injurious and non-injurious laboratory reconstructed football impacts

Studies of concussive events have shown that the response of the brain during an impact may not be the most reliable predictor of concussion, since the injury may be more closely related to the forces affecting the brainstem. A laboratory crash test protocol was developed to simulate player-to-player collisions in contact sports using crash test […]

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NMR analysis of the enzymatically produced propylene glycol mono- and di- esters of canola oil

Emulsifiers as multifunctional additives can develop low-caloric, high-quality foods. Beside the monoacylglycerols (MAGs), or mixtures with diacylglycerols (DAGs), propylene glycol (1,2-propanediol) esters (PGEs) are the commonly used emulsifiers in the food industry. Emulsifiers are currently produced using costly and environmentally unfriendly “enzyme in solvent” systems and also have some shortcomings in certain food applications. This […]

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Understanding the cellular mechanisms sustaining functional capacity improvement with prehabilitation in colorectal cancer patients

Cancer is associated with weight loss, decreased muscle strength and inflammation. This has a tremendous impact on daily activity, autonomy and quality of life, involving both patients and care-givers. I previously worked on a preoperative intervention called ‘pre-habilitation’, a personalized exercise and nutritional supplementation delivered before surgery. The main idea is to prevent postoperative complications […]

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