A new revolution in life science research is ongoing since the discovery of the CRISPR/Cas system. With this technology is now possible to specifically and efficiently manipulate the genome of cultured cells, embryos and animals. The technology has many applications in agriculture including the dairy genetic industry to generate the next generation of elite animals […]

AVID100 is an antibody-drug conjugate (ADC) against a validated cancer target that is undergoing IND-enabling studies. Phase I clinical trials are scheduled for late 2016. The monoclonal antibody (mAb) portion of the ADC is currently manufactured using a recombinant CHO clone that fails to meet industrial production yield standards. In order to support clinical phases […]

Chronic rhinosinusitis is a common condition in which the cavities in the nasal channel become inflamed and swollen. This condition interferes with drainage and causes mucus to build up. Delivery of the positively charged proteins containing short chains locally to the nasal area can be used for the treatment of this problem. This proposal suggests […]

Traditional research microscopy tools are entirely adequate for conventional static analysis, however, the evaluation of more complex dynamic cellular processes require unconventional methods of acquiring, displaying, and rendering dynamic data. Autophagy occurs when some of a cell’s cytoplasm, referred as cargo, is enclosed by a membrane to form an autophagosome in order to be degraded […]

La production d’enzymes d’intérêt industriel doit être maximisée pour que ces derniers soient viables commercialement. Diverses approches peuvent être envisagées pour optimiser cette production et les techniques de biologie moléculaire peuvent participer à cet objectif. Des gènes synthétiques codant pour différentes formes d’estérase ont déjà été conçus mais la production des enzymes est réduite suite […]

FPInnovations a récemment procédé à l’évaluation de différentes activités biologiques de résidus de plusieurs essences ligneuses canadiennes. Certains extraits ont montré des résultats intéressants au niveau de différentes activités biologiques testées telles que les activités antioxydante, antifongique, antibactérienne, etc. Parmi ceux-ci, les extraits d’écorces de cèdre rouge de l’Ouest (Thuya plicata) ont montré une activité […]

Botanical extracts with the potential to stimulate crop plant growth or performance must be rigorous tested as part of new product development. Similarly, botanical extracts that control microbial growth on plant tissues (including plant pathogenic fungi, bacteria, nematodes, etc.) or that control insect or arachnid pests on plants (aphids, whiteflies, mealybugs, mites, etc.) must be […]

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing […]

Depuis les dernières années, les punaises de la famille des Pentatomidae posent de plus en plus de problèmes dans la culture du pois au Québec. Bien que la présence de ces dernières sur les plants ne provoque pas de pertes de rendement significatives, elles contaminent toutefois les récoltes. Leur ressemblance au pois, quant à la […]

Dementia involves significant memory loss and represents a major public health threat. Brainwave technologies can be used to monitor brain changes in the process of dementia. The proposed study is to apply the latest research advancement of brainwave technologies, called NeuroCatch. A hundred older adult participants with dementia and with cognitively normal aging will have […]

Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently […]

Cheng Qian (PhD candidate) supported by this Mitacs Globalink Program will go to Nanjing (P. R. China) and work in a cooperative project under the supervision from Prof. Dr. David Chen (University of British Columbia, Canada) and Prof. Xiaohua Huang (Nanjing Normal University, P. R. China) to install a novel electro-ionization interface for high resolution […]