Smart mutational exploration of the CalB lipase active site using a combination of virtual screening and iterative saturation mutagenesis

The company Odyssée Biotech specializes in the production of natural flavors and fragrances using innovative enzyme technologies. Using natural enzymes allows the enterprise to produce highly pure ingredients in mild conditions with a natural label. This green approach also makes this technology highly competitive and environmentally sustainable relative to other production methodologies employed in the […]

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Développement de nouveaux actifs et de nouvelles formules pour le secteur du cosmétique

Avec un marché qui devrait dépasser les 200 milliards de $ US en 2020, le domaine des produits cosmétiques et un moteur économique important à l’échelle mondiale, mais également canadien. Cette activité requiert de la part des entreprises un investissement important en recherche et développement afin de rester compétitive face à la concurrence. Cette proposition […]

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Development of new approaches to promote proliferation of insulin producing pancreatic ?-cells in diabetic patients

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]

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Development of a diagnostic assay for first line detection and surveillance of bladder urothelial carcinoma using concurrent biomarker panels from non-invasive liquid biopsies

Bladder Carcinoma (BC) is the fifth most common cancer in Canada. Although most individuals have surgery to remove BC tumors, the risk of another BC developing and/or progressing to invasive disease is high so long-term surveillance is necessary. The current method for screening for BC is not sensitive enough, and individuals often end up undergoing […]

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Deciphering the role of the tumor suppressor p53 in regulating treatment-induced ovarian cancer cell fate decisions in vivo

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that […]

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Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

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Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy – Year 2

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

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Improving signal processing in hearing aids to support music and emotional speech

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing […]

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Delivery of DNA nanoparticles coding for an immunosuppressive agent (ISA-PP) to gut mucosa for GvHD treatment

Bone marrow transplantation is an effective treatment for blood-related malignancies. However, it frequently results in graft-versus-host disease (GvHD), a life-threatening condition where donor immune cells attack host tissue. It is due to individual genetic differences, present even when the donor is closely related, and results in damage to several organs including skin, liver and digestive […]

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