It has been established that foam rolling can increase range of motion, reduce exercise-induced soreness and improve performance. An imbalance of hamstrings to quadriceps strength is associated with an increased incidence of lower limb injuries. The effect of rolling one muscle (e.g. quadriceps or hamstrings) or a pair of muscles on the antagonist muscle has […]

Biomarkers that can reliably detect Alzheimer’s Disease (AD) are essential for disease monitoring and development of drug therapy. We have shown that a protein, melanotransferrin (MTf), is elevated in the blood of humans with AD but is nearly undetectable in age-matched healthy controls. We will further validate MTf as a biomarker in mouse models of […]

Ticks contain many different disease-causing bacteria and viruses, including the bacteria that causes Lyme disease. Multiple infections with these other pathogens in addition to Borrelia cause more severe illness. For many of these pathogens there are no or limited diagnostic tools available to detect the pathogen. This project includes production of a new product, “a […]

The intern will analyze blood samples of patients with high-risk prostate cancer. The cancer cells will be isolated from the blood sample and the genetic material will be stained and then imaged by a high-intensity-high-focus 3D microscope. Next, the telomeres (ends of genes) will be studied and compared. The point is to see the progression […]

The great number and variety of factors influencing the survival of migrating salmon smolts in the early marine environment makes it difficult to understand the causes of recent declines in smolt survival and salmon population productivity. We will combine novel methodologies (biotelemetry and biomarkers) simultaneously to examine a variety of factors influencing the migratory behaviour […]

Access to efficient drugs to treat diseases that affect Canadians is among the highest priorities of our society. The development of new medicinal agents depends on the access to small molecules capable of interacting with biological targets associated with those diseases. These small molecules are typically identified by screening large collections of synthetic compounds. Paraza […]

The intern will conduct a research study to evaluate whether measuring insulin in saliva can be used to reflect levels of insulin in the blood. The long-term objective is to work with the industry partner to develop a non-invasive personal salivary insulin monitor using a new technology that is in development that can quickly and […]

Understanding the underlying factors that cause inherited diseases to develop is an important step in improving the health status of individuals, and identifying effective prevention and control measures. This project aims to apply fundamental knowledge of genetics, genome sequence analysis, modeling and simulations, and bio-informatics to uncover the relationship between these factors and assess the […]

Qu Biologics is a clinical-stage biopharmaceutical company developing and evaluating an innovative immunotherapeutic approach to treating disease rooted in immune pathology/dysfunction. Qu’s proprietary technology platform, site-specific immunomodulators (SSI), act to stimulate the body’s own immune system to reverse the chronic inflammation underlying many conditions including cancer and immune-mediated diseases. For lung diseases, Qu’s platform SSI, […]

The blood of cancer patients contains DNA that has been shed by their tumours (circulating tumour DNA or ctDNA). As such, any genetic mutations in the tumour may be detected in the patient’s blood. Theoretically, patients can be followed and monitored through analysis of ctDNA, which would reveal if the patient is responding to treatment, […]

Cancer cells are known for their unique capacity to survive and grow in a low oxygen tension environment in the middle of a poorly vascularized solid tumor. This adaptation, which is central to the tumorigenesis process, is mediated by precise cellular mechanisms allowing the regulation of gene expression. Thus, the development of small molecules to […]

Rates of obesity are continuously rising despite efforts to decrease them. The purpose of this study is to show that obese but fit individuals are protected from many adverse health conditions such as metabolic syndrome, insulin resistance, type-2 diabetes, high blood pressure, and cardiovascular disease as the result of being physically active. This study is […]