With an average median survival of 14 months, glioblastoma multiforme (GBM), the most common and most aggressive primary brain tumor occurring in adults, represents an unmet medical need and new therapeutic options with a significant impact on patients survival are eagerly awaited. Our laboratory recently identified the enzyme CD73 as a new target for cancer […]

With an average median survival of 14 months, glioblastoma multiforme (GBM), the most common and most aggressive primary brain tumor occurring in adults, represents an unmet medical need and new therapeutic options with a significant impact on patients survival are eagerly awaited. Our laboratory recently identified the enzyme CD73 as a new target for cancer […]

En collaboration avec des experts en biologie moléculaire, SPI Biosensing procède à la mise au point d’un appareil autonome permettant la détection en temps réel de pathogènes bactériens présents, entre autres, dans les procédés industriels. Ce système innovateur repose sur de l’imagerie des plasmons de surface couplée à un biosenseur dont la propriété est de […]

En collaboration avec des experts en biologie moléculaire, SPI Biosensing procède à la mise au point d’un appareil autonome permettant la détection en temps réel de pathogènes bactériens présents, entre autres, dans les procédés industriels. Ce système innovateur repose sur de l’imagerie des plasmons de surface couplée à un biosenseur dont la propriété est de […]

Ce projet vise à élucider davantage le mode d’action de certains produits élaborés par ProMetic BioSciences inc. sur certaines cellules myéloïdes humaines en relation avec une réponse cellulaire impliquée dans un nombre grandissant de maladies humaines. Il s’agit d’un stress du réticulum endoplasmique (RE), un organite cellulaire impliqué dans la synthèse des protéines. Cette dernière […]

Ce projet vise à élucider davantage le mode d’action de certains produits élaborés par ProMetic BioSciences inc. sur certaines cellules myéloïdes humaines en relation avec une réponse cellulaire impliquée dans un nombre grandissant de maladies humaines. Il s’agit d’un stress du réticulum endoplasmique (RE), un organite cellulaire impliqué dans la synthèse des protéines. Cette dernière […]

Glioblastoma (GBM), the most aggressive primary brain tumors in adults, is feared for its near uniformly fatal prognosis. Due to its infiltrative nature, surgery alone is ineffective in disease eradication. We originally identified abnormal cancer stem cells called brain tumor-initiating cells (BTICs) that lead to the formation of this brain tumor. These BTICs are known […]

Synthetic plastics in which one could easily tailor the overall structure and incorporate desired functions with ease continue to be at the forefront in research for biomedical applications. The synthetic challenges in constructing such complex structures could be overcome by introducing simple and high yield reactions which could help streamline their availability on a large […]

Drug use in older persons is a major public health concern. Even though therapeutic drugs are beneficial for patients’ health in terms of survival or quality of life, patients aged >65 years have a greater risk of developing drug-related complications. Such complications may be fatal because of the high frequency of both multiple pathologies andpolypharmacy […]

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) […]

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) […]

Streptococcus agalactiae (S. agalactiae) is a worldwide-distributed bacterium. It is a major infectious agent to humans, cattle and aquatic animals. The outbreak and prevalence of S. agalactiae in aquaculture has been reported in different countries as one of the major causes of mortality leading to serious economic losses and threatening the sound development of aquaculture. […]