The proposed project, performed with the company Immune Biosolutions, aims to develop superior antibodies for biological targets of interest for the treatment of colorectal cancer. Specifically, these targets are a class of proteins expressed on cell surface, which are notoriously difficult for the development of antibodies. The method involves making molecules look like the biological […]

Ce projet de recherche porte sur le développement d’un ingrédient cosméceutique préparé à partir d’un extrait de feuilles de brasénie, une plante aquatique répandue au Canada. Le premier objectif du projet est de procéder à une analyse plus approfondie de la composition chimique de l’ingrédient en déterminant la teneur en tanins hydrolysables et en identifiant […]

Lactating dairy cows have extensive embryonic loss, but the mechanisms that lead to this failure to maintain pregnancy are not clearly understood. It is suggested that high-producing dairy cows are marginally deficient in nutrients such as Vitamin B complex molecules, selenium etc., which are positively associated with health and reproduction. The goals of the project […]

The world’s rapidly changing climate is influencing how insects can transmit dangerous infectious diseases – from malaria to dengue fever and other previously unknown diseases – to humans. The rapid growth of new data sources from satellites to ground based sensors offer unprecedented opportunities to link these data with knowledge of the biology of insects […]

Phyto-pathogenic fungi are one of the main concerns threatening agriculture in Canada. Those phyto-pathogens not only affect the yield and the quality of agricultural products, but their metabolite, represented by mycotoxins, will also endanger food safety. In the pursuit of innovative environmental-friendly fungicides, oxylipid is of great research-importance because oxylipid with specific structures can act […]

This project involves three streams, all focusing on the effects of low-dose ionizing radiation. The first stream examines the effects of single ion irradiation using the Microbeam at McMaster University. Preliminary biological research will be conducted on human cell lines using standard radiobiological endpoints including DNA double strand break foci and micronuclei formation. The second […]

In the egg industry, as the hens are at the end of their productive lives they are of little economic value to the farmers and seen as a by-product or a waste which require disposal. Disposal of spent hens is a long-existing liability to the egg industry for paying associated cost of handling, transportation and […]

The promotion and maintenance of women’s pelvic floor health is a growing concern as pelvic disorders affect a substantial number of women and their prevalence is expected to increase as a result of Canada’s aging population. Pelvic floor disorders go beyond their physical consequences as they can negatively impact women’s psychological, sexual, and social quality […]

Pseudomonas aeruginosa is a Gram-negative pathogen that is frequently related to nosocomial infections. The bacterial biofilm controlled by quorum sensing system allows P. aeruginosa to adhere to any surface and protect it from antibacterial treatments, such as antibiotics and heat treatment. The novel invention strategy developed in this project is to inhibit P. aeruginosa biofilm […]

Végétamix Inc, commercialise des jus de légumes traités par des hautes pressions (HPP) et désire développer une purée d’ail biologique pour l’ajouter à sa gamme de produits. L’ail transformé est très instable et on doit ajouter des agents de conservateur pour palier à plusieurs problèmes comme la diminution de la valeur nutritive et le changement […]

Mesenchymal stromal / “stem” cells (MSCs) are found in adult tissues such as bone marrow and fat and also in neonatal tissues such as the placenta and umbilical cord. Among these sources, Human Umbilical Cord PeriVascular Cells (HUCPVCs) are the richest source of MSCs described. Importantly, they possess immunomodulatory and immuneprivileged properties which enable them […]

Allergic rhinitis is an inflammatory condition of the nasal passages induced after allergen exposure in sensitized individuals. Approximately 20-25% of Canadians suffer from allergic rhinitis, with cat allergy affecting up to 15% of people with allergic rhinitis and/or asthma. Although existing immunotherapies have some effectiveness, these have safety problems and require long-term treatment. A novel […]