The World Health Organization estimates trauma causes 5 million deaths each year, 90% of those deaths occurring in low-to-middle income countries. While improved outcomes have been noted when resources are focused on improving staff training, infrastructure, supplies availability, and process organization, the burden of injury in Kenya is not fully known and significant injury and […]

Lake Whitefish (Coregonus clupeaformis) are currently the subject of research to obtain Marine Stewardship Council certification for the fishery in Lake Erie. The declines of Lake Whitefish stocks in Lakes Huron, Erie and Ontario have drawn much concern from the fishing industry, regulators, and other stakeholders. Better estimates of the stock status are needed to […]

Dental hygienists (DH) are exposed to many potentially injurious physical demands, such as prolonged exposure to awkward neck, trunk, and shoulder postures. The prevalence of musculoskeletal disorders in this group is alarmingly high (62-93%). DH would benefit from ergonomics-specific workplace safety education, but it is unknown what sort of instruction, if any, is currently offered […]

It is not well known that the majority of breast cancer patients do not receive a survival benefit from chemotherapy. Yet, they experience many negative short- and long-term side effects from chemotherapy. This is also the case for other cancers. There is thus a clear, unmet need for a diagnostic tool that can reliably identify […]

While chemotherapy drugs are effective in combating tumour growth in cancer patients, many such drugs permit the development of drug-resistant tumours and progression of the disease. We have observed that several chemotherapy agents induce the degradation of tumour cell ribonucleic acid (RNA) in the laboratory and in cancer patients. We have further shown that this […]

The goal of neurosurgery are two folds, 1) to achieve maximal resection of the target lesions, but simultaneously 2) minimize damage to adjacent healthy brain tissues. Currently surgeons rely on preoperative images such as Magnetic Resonance Imaging to define tumor boundaries. However, the accuracy of such images decreases intraoperatively due to brain shift. For these […]

Peritoneal Mesothelioma (PM) is a rare type of cancer affecting the protective membrane surrounding the abdominal cavity and the second most common type of mesothelioma, consisting about 10-20% of the diagnosed cases. The underlying cellular and molecular mechanisms of peritoneal mesothelioma pathology are greatly understudied. In this proposal, we aim to enhance the current knowledge […]

With the increasing numbers of economically motivated food adulteration, sensitive, rapid, portable, and cost-effective detection techniques for food fraud is highly demanded. Ground beef products have the potential to be adulterated by the livestock’s by-products, such as beef and pork offal. Traditional techniques failed to meet the requirements by government, food industry, and consumers (i.e. […]

Antimicrobial resistance threatens effective prevention and treatment of microbial infections. Over two million hospitalized patients acquire infection from antimicrobial resistant microbes resulting in more than 23,000 deaths in North America. Therefore, development of a novel class of antimicrobials is in urgent need. The goal of our research project is to develop a novel antibiotic for […]

The study focuses on the assessment of motor proficiencies of children before and after their involvement in a specialised recreation program, when compared to children of the same age who are enrolled in standard parent-selected programming. The specialised program sets at introducing children to a wide array of activities in multiple environments, and are taught […]

The success of Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), lies in its ability to primarily infect, reside, and multiply in the lungs of patients. Mtb infects white blood cells termed alveolar macrophages and hides from the host immune response as well as from many antibiotics used for treatment, creating additional challenges for […]

There is a critical need for new therapies for Parkinson’s Disease (PD), a devastating neurodegenerative disease. Current therapies for PD treat disease symptoms, but do not provide a cure. The ability to generate patient brain-derived cells may rapidly advance development of personalized therapies for PD and other incurable neurological disorders. This study will use brain […]