Chromosome Engineering for Bioproducts from Methanotrophs – Year Two

Currently Metagenom Bio Inc. offers contract research services in environmental microbial species profiling. Applications for this service include the monitoring of biogas operations, greenhouses, and mining processes. Metagenom Bio wishes to offer solutions that use microbes to generate value-added products. Biogas reactors can break down waste products and produce methane, or natural gas. This methane […]

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Identification et caractérisation de triterpènes à partir du thé du Labrador (Rhododendron groenlandicum) et leurs applications cosmétologiques

L’industrie cosmétique s’intéresse de plus en plus à des molécules naturelles pour le développement de nouvelles formules cosmétiques. Le présent projet vise à mieux comprendre les propriétés cosmétiques du thé du Labrador qui est utilisé il est préconisé l’utilisation de certains de ces actifs naturels avec un fort potentiel anti-inflammatoire dans des applications cosmétologiques. Depuis […]

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Development of eDNA monitoring tools and protocols for assessment of Western Painted Turtles (Chrysemys picta bellii) in British Columbia.

Environmental DNA (eDNA) sampling uses genetic material from the soil or water to detect the presence of an organism. This method has been used to detect endangered and introduced species, especially those that are rare and hard to detect. Although using eDNA to detect species has been successful, the method must be altered and changed […]

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Effects of natural gas development on density and reproductive success of grassland birds in south-western Saskatchewan

Native grasslands in Saskatchewan provide important breeding habitat for many grassland birds, including species at risk. However, conservation agencies are concerned that the quantity and quality of remaining grasslands in south-western Saskatchewan may currently be threatened by expansion of natural gas development. Agriculture and Agri-Food Canada manages large grassland parcels and seeks to maintain a […]

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The development of single-cell RNA-sequencing methods for identification of biomarkers and therapeutic targets in leukemic stem cells

Targeted cancer therapies have significantly improved the treatment of leukemias, but emergence of treatment resistance and subsequent cancer relapse significantly reduces patient survival. This relapse is primarily caused by the inability of current therapies to eradicate leukemic stem cells. It is currently extremely challenging to study these stem cells, due to its rarity in patient […]

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TARGETING CANCER TUMORS USING A NATURALLY REFINED PARASITE HOST ANCHOR PROTEIN

In this project we will combine knowledge from two different research fields, namely parasitology and cancer biology, to develop a novel approach to target a variety of cancer tumors with high specificity. The malaria parasite P.falciparum has evolved a protein (VAR2CSA) that allows infected human blood cells to bind a sugar structure called CSA on […]

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Developing an Indigenous-led ‘conservation economy’: Ecosystem service synergies and trade-offs from shellfish aquaculture in British Columbia’s Great Bear Sea

Without careful management, the growing number and intensity of human activities can negatively affect ecosystem health and cause conflict between users. Recognizing the need for integrated management, the Province of British Columbia and 18 Coastal First Nations collaborated to develop an integrated spatial Marine Plan for the North Pacific Coast. A critical part of implementing […]

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Long-Term Ecosystem Monitoring of the British Columbia Coast across a Gradient of Human Stressors

Proposed developments (pipelines, super-tankers) along the coast of BC have the potential to negatively impact (shell)fisheries. Direct monitoring of fisheries can only detect negative impacts which have already occurred; therefore, indicator species (meiofauna) and environmental variables are monitored to detect disturbances before productivity is impacted. Our project will monitor intertidal ecosystems (numerous species and environmental […]

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Long-Term Ecosystem Monitoring of the British Columbia Coast across a Gradient of Human Stressors – Year Two

Proposed developments (pipelines, super-tankers) along the coast of BC have the potential to negatively impact (shell)fisheries. Direct monitoring of fisheries can only detect negative impacts which have already occurred; therefore, indicator species (meiofauna) and environmental variables are monitored to detect disturbances before productivity is impacted. Our project will monitor intertidal ecosystems (numerous species and environmental […]

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Research cluster for Precision Medicine in Oncology

New therapeutic approaches are desperately needed for many types of cancer. This training cluster brings together five academic experts who will each mentor a trainee to establish a panel of novel cancer models in one of the following: glioblastoma stem cells, renal carcinoma cells, pancreatic tumor organoids, leukemic cells and tumor reactive T-cells – all […]

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Insight into mechanisms and receptor(s) involved in PBI-4050’s beneficial effect on kidney fibrosis and inflammation

PBI-4050 is a novel compound developed by ProMetic Life Sciences Inc. possessing anti-inflammatory and anti-fibrotic effects. PBI-4050 targets a family of cell receptor(s) expressed throughout the body, which are involved in diseases marred by fibrosis and inflammation. The first aim is designed to test PBI-4050’s efficacy preserving kidney function in a mouse model of advanced […]

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