Cardiovascular disease and sepsis are two of the biggest public health problems in North America. Increasing evidence further suggests they are linked. Recent studies in human healthy volunteers and in chronic heart failure patients have highlighted the apelin system as a potential target for drug development. We therefore propose to fully validate pre-clinically the potential […]

Breast cancer is the most frequent cancer affecting women, with 1 in 9 Canadian females expected to develop the disease in their lifetime. About 90% of estrogen receptor (ER)-positive breast cancers express androgen receptor (AR). Recent results in our laboratory demonstrated that the inactivation of 5alpha-dihydrotestosterone (DHT), the most potent androgen, contributes to estrogen-dependent breast […]

The overall objective of this work is to gain a better understanding of the experience of patients living with acne and how to support their decision making process in terms of acne treatment options. This research will investigate issues surrounding how patients understand how to accurately determine the severity of their acne and the treatment […]

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]

Intern will be determining active ingredients in Iceberg mist which is a toner based on iceberg water. Several tests will be conducted to determine the antioxidant potential of this product. The partner organization will be able to make a claim on the product using the information based on this project which will help in marketing […]

Planter des arbres dans les bandes riveraines de milieux agricoles a de nombreux avantages. Les arbres diminuent la pollution des eaux, limitent l’érosion et améliorent le cadre de vie des gens. Toutefois, la biodiversité végétale des bandes riveraines peut parfois ne pas se rétablir suite aux plantations d’arbres. Tout dépend des graines présentes dans les […]

Patients with cervical spine degeneration are difficult to diagnose and treat. Some patients will not benefit from surgical intervention while others require immediate surgical management to avoid permanent neurological deficits. Distinguishing between these patient groups is very difficult, and not effectively done with current protocols. Medical imaging is part of the current diagnostic protocol for […]

Le gouvernement du Québec et les entreprises s’orientent vers un aménagement forestier durable de nos écosystèmes forestiers afin d’en conserver la biodiversité et une croissance optimale. Ce projet s’inscrit dans cette lignée, il a pour but d’étudier l’influence des variables environnementales, notamment les perturbations naturelles et anthropiques sur les communautés de sous-bois de la forêt […]

Proper brain development is required for normal cognitive functions in mammals. Recent studies have shown that both protein-coding genes and noncoding RNAs, especially microRNAs (miRNAs), play crucial roles in brain development. We have identified several miRNAs that are expressed in specific regions in the embryonic and adult mouse cerebral cortex, and demonstrated their important roles […]

For people with lower limb amputations, the interface between the amputated limb and a prosthetic socket is very important. Suspension, or how the socket is held on the limb, is one factor that affects a person’s ability to walk efficiently and safely, movement confidence, limb health, and quality of life. This project will assess, evaluate, […]

The goal of this Mitacs research proposal study is to develop and apply experimental methodology for transdermal delivery of bone-targeting peptide hormone drugs. We aim to deliver these compounds using an appropriate hydrophilic-hydrophobic Diffusimax liposomal drug delivery cream base to anatomically superficial bone, at the sites of stress fractures (also known as “shin-splints”) in order […]

Le PBRM est un inhibiteur de la biosynthèse des estrogènes ciblant la 17 betahydroxystéroïde déshydrogénase type 1, une enzyme impliquée dans la dernière étape de la production de l’estradiol et qui pourrait être avantageusement utilisée pour traiter certaines maladies estrogéno-sensibles comme le cancer du sein et l’endométriose. Cet inhibiteur unique, par sa capacité à inhiber […]