Preclinical characterization of medical marijuana cultivars with therapeutic efficacy and low side-effect liability

Medical marijuana describes the legal use of cannabis plants for treating health-related issues. In Canada, there are currently about 40,000 medical marijuana users, and this number is expected to increase by over 1000% during the next decade. The large majority of patients use medical marijuana for its psychological effects, such as for anxiety, depression, pain […]

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The impact of the physical and social environment on epigenetic modifications, telomere length and the development of breast cancer

Recent studies have shown that interactions between beings and the environment, including social practices and human behavior, have an impact on the susceptibility to develop chronic diseases such as cancer, through epigenetic modifications or telomere shortening. The term epigenetic applies to the modifications that regulate gene expression without modifying the DNA sequence. Furthermore, telomere is […]

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Statistical advancements in the analysis of migratory movements using a novel broad-scale automated radio-telemetry array.

Partnerships among researchers and corporations are continually pushing the advancement of animal tracking technology, allowing smaller animals to be tracked for longer periods, over greater spatial scales, and at finer scale spatial resolutions. Yet the statistical analyses of these data is lagging behind. Using a novel, state-of-the-art network of 57 automated telemetry arrays distributed across […]

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Investigating the effect of heat stress on the early life microbiome in Japanese dairy calves

Climate change is creating urgent challenges for livestock farming, as rising temperatures and more frequent heat waves reduce animal health, productivity, and welfare. Young calves are particularly vulnerable because their immune and temperature regulation systems are not fully developed, and their gut microbiome—the community of bacteria, archaea, and viruses that support digestion and health—is still […]

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Biomaterial derived dendritic cells for regenerative medicine

This project will establish a commercially viable, regenerative biomaterial-based method for effective, reduced-cost and clinically feasible culture of immune cells for immune cell therapies. Argan Biomedical Technologies inc, partnering with the Sefton lab at UofT, has developed technology that uses regenerative synthetic biomaterials to reduce the use of expensive and otherwise problematic biological components used […]

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Impacts of hydroelectricity production on aquatic ecosystems: Development of key environmental indicators for Life Cycle Assessment (LCA) approach

In boreal and temperate regions, dams are mainly constructed to provide ecosystem services such as hydroelectricity production. River impoundment and the alteration of natural hydrological regimes are suggested to be major disturbances to aquatic ecosystems. To meet long-term environmental objectives for sustainable development, Hydro-Quebec recently adopted the Life Cycle Assessment (LCA) approach. LCA is an […]

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Mieux comprendre pour mieux cibler : exploration intelligente des indications oncologiques adaptées aux thérapies conditionnelles

9Bio est une entreprise spécialisée dans l’ingénierie de protéines thérapeutiques pour l’oncologie. Cette jeune pousse a développé une plateforme de biologie structurale computationnelle dont le but est d’aider à la conception de traitements thérapeutiques qui ciblent sélectivement les tumeurs en fonction des signatures métabolomiques et chimiques uniques du microenvironnement tumoral, tout en épargnant les tissus […]

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Impacts de la production d’hydroélectricité sur les écosystèmesaquatiques : Développement d’indicateurs environnementaux pourl’approche du cycle de vie (ACV)

In boreal and temperate regions, dams are mainly constructed to provide ecosystem services such as hydroelectricity production. River impoundment and the alteration of natural hydrological regimes are suggested to be major disturbances to aquatic ecosystems. To meet long-term environmental objectives for sustainable development, Hydro-Quebec recently adopted the Life Cycle Assessment (LCA) approach. LCA is an […]

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Rapid next generation infectious disease diagnostics for tuberculosis and leptospirosis

Infectious diseases remain one of the largest killers of the human population and disproportionately so in developing countries. Assays for the rapid and comprehensive identification of causative strains of the infectious disease agents in tuberculosis and leptospirosis is currently lacking. These infections represent over 20 million cases annually. Existing diagnostic protocols involve lengthy and resource-intensive […]

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High-Affinity Selective DNA Intercalators (HASDI): A novel approach to interfere with the transcriptional activity of disease-causing transcription factors

Cancer is a complex disease that involves multiple changes in normal cell biology, all of them leading to increased and abnormal cell replication. Depending on the tissue type, this uncontrolled tissue growth ultimately causes organ malfunction and a wide variety of signs and symptoms which, all together, indicate a pathological state which needs to be […]

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