Small Molecule-Promoted Acceleration of Beta-Amyloid Aggregation

The progression of Alzheimer’s disease is strongly linked to small beta-amyloid polymers found outside the neurons of the human brain. These polymers interact with neurons and disrupt their function, leading to the neurodegenerative symptoms seen in Alzheimer’s patients.
However, certain small molecules are able to promote the aggregation of these polymers into large fibril structures, which are both less toxic and less pathogenic. We will be testing two small molecules which have the potential of causing this aggregation effect to see their mechanism of action and determine whether or not they can diminish the symptoms of Alzheimer’s disease. If shown to be safe and effective, these molecules can be incorporated into medication to treat patients with the disease.

Faculty Supervisor:

Lisa Münter

Student:

Partner:

Beijing Normal University

Discipline:

Life Sciences

Sector:

Education

University:

McGill University

Program: