Glutamate-induced allosteric potentiation of GABAA receptor: a novel mechanism of Purkinje cells inhibitory plasticity

Our brain is controlled by two systems: excitatory systems and inhibitory systems. The balance between these two systems is essential for normal brain functions. Our lab has found that glutamate, a key neurotransmitter in excitatory systems, can act at GABAAR, a key receptor in inhibitory system, and improve GABAAR’s function. This is a novel form […]

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Multi-dimensional wellbeing: Examining how financial, social, health, and environmental factors interactively determine subjective wellbeing

Maintaining a high level of subjective wellbeing (SWB) is critical to a happy and productive life. To achieve happiness, it is important to know what factors determine SWB. So far, a number of factors have been identified, including income, social relationships, physical health, and the environment. However, it is currently unknown how these factors interact […]

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Heap leaching of refractory gold ore by integrating enhanced bio-oxidation of pyrite and chloride-based gold leaching

Gold occurs in association with pyrite and arsenopyrite in the Carlin-type gold deposit, with little gold being contained in carbonaceous materials. Extracting this gold requires pretreatment, such as pressure oxidation or roasting, to remove carbonaceous materials and sulphides, followed by the application of alkali cyanide or thiosulphate solution to leach gold. These processes are energy-intensive […]

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Assessing the spatial and temporal distribution of snow for climate change impacts and its influence on wildlife habitat selection

Annual snowpack data is typically summarized at a regional scale and used to make forecasts for spring melt conditions and flooding. However the spatial pattern of snow, its accumulation and melting across the land base, also directly influences the movement and habitat selection for many wildlife species which in turn impacts forest harvesting and resource […]

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Challenges for drug-using mothers with children in the care of family members

The purpose of the study is to identify and respond to experiences of and potential challenges faced by drug-using mothers when their children are placed in the care of family members (otherwise known as “kinship care”) as an alternative to a formal foster care placement. As an outcome, we will develop an information package for […]

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Computer Assisted Drug Design of Therapeutic Hydroxyarylmethane Derivatives

Aurin Biotech has demonstrated that aurintricarboxylic acid (ATA) and related hydroxyarylmethane derivatives are potent inhibitors of the terminal complement cascade. The complement cascade is a potent initiator and enhancer of the inflammatory response which leads to pathophysiological consequences including cell death and tissue remodeling in a range of chronic diseases. This project uses two distinct […]

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Relationships between parental self-efficacy, parent training instructional practices and models of parent professional interaction

Research has shown that parents of children with autism have lower levels of self-efficacy (i.e., self-perceptions of their ability to nurture their children’s growth and development) when compared to other parents. This is problematic, as parents who feel more confident and effective when implementing intervention strategies and who believe that their involvement has a positive […]

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Blood flow within microfluidic conduits

A current area of focus at SMT Americas is to develop injection-moulding methods for medical lab-on-chip (LOC) devices, particularly to transport and process blood and plasma while eliminating conduits clogging and reducing sample loss. This project will evaluate the effect of flow conditions on viscosity of samples, and the adequacy of conduit structures achieved with […]

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“El Yerro Barroco / The Baroque Error”

Baroque is defined as an irregular pearl, and it is described as an oddity. This oddity or kink, as defined in the dictionary, hints at how the baroque that Spain created transcended an artistic style. In Spain during the XVI century, including the conquest in 1521 in Mexico all the way to the beginning of […]

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Deconvolution of Whole Blood Transcriptome based on mRNA-Seq data

Gene expression in blood is highly affected by the type and proportion blood cells. Therefore, cell composition needs to be taken into account when looking for signatures specific to a condition. The issue is that cell composition needs to be assessed on fresh blood, i.e. at time of blood collection. If this has not been […]

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Kinetic and Reactor Models for Sugar-to-Glycol Conversion

The sustainable use of forest- and agriculture-based resources to produce clean fuels and value-added chemicals is an opportunity to reduce greenhouse gas emissions generated by non-renewable fossil fuels. Glycol, a valuable industrial chemical, can be derived from sugars that originate from agricultural and forest waste and byproducts using a catalytic process. S2G Biochem, located in […]

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