While satellite cell (SC) activation underpins muscle repair, function requires reinnervation of new myotubes. During early differentiation in repair, SC-derived myoblasts also upregulate expression of a neural chemorepellent, semaphorin3A (Sema3A), thought to mediate axonal ingrowth toward regenerating myotubes. Recent findings indicate that disrupted timing of Sema3A expression (by early SC activation) delays the time-course of […]
Read More