Functional and structural characterization of clinically relevant amyloid fibrils

Irreversible, progressive, and incurable neurodegenerative diseases, such as Alzheimer’s disease (AD) or Parkinson’s disease (PD), constitute severe challenges for the modern and, in particular, for the healthcare system. Recent reports suggest that worldwide >50 Mio. people and >10 Mio. people are living with AD or PD, respectively. Both diseases are related to protein misfolding and […]

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The Effect of Droplet Size on Automotive Paint Colour

Spray painting in the automotive manufacturing industry is an extremely difficult technical challenge. Approximately 25% of cars coming off the assembly line must be reworked or scrapped due to a poor paint job. Previous research has shown that the droplet size distribution of the paint being applied to the car is important for the final […]

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Negotiating Resource Production, Conservation and Recreation Values in Canadian Wild Food Forest Habitats

Commercial sourcing of wild foods, such as chanterelle mushrooms or wild blueberries, often requires accessing forests with competing uses. They might also be timberlands for conventional forestry, or parks for recreation or conservation. The conflicts that result illustrate how nature and natural resources are valued in different ways in different worlds: by forest managers or […]

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Pharmacodynamic distribution of docetaxel andcabazitaxel in prostate cancer xenografts, and evaluation of pantoprazole to enhance their activity

Chemotherapy drugs target and kill rapidly-dividing cells located closest to blood vessels, but do not penetrate deep into the tumor. Limited drug distribution in tumors is an important cause of drug resistance. A method to increase tumor drug delivery and combat resistance is the subject of this proposal. To counteract chemotherapy resistance, the use of […]

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Learning to Predict Grasp Outcomes

With the growing importance of ecommerce, automated warehousing has gained much interest. A crucial component of such system is a robotic arm or a similar device that allows to grasp, pick up and sort items with complex shapes and in cluttered conditions. We will be working on improving such system, so that online delivery can […]

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Improved inhibitors of HIV infection

ViroCarb has identified a new class of HIV inhibitors against a new therapeutic target on the HIV envelopeprotein gp120, present in all HIV, including drug resistant strains. The objective of this internship is to conduct screening studies of libraries, designed based on this new chemical class for optimal efficacy and drug-like properties, using methods previously […]

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Using AI to Increase Diversity in the Talent Pool

Canada is having a youth unemployment crisis that has only worsened post-COVID. At the same time, an untapped pool of young, diverse talent exists to fill entry-level positions. However, difficulties arise when trying to match youth with employers. In particular, youth have indicated that job postings can be unfamiliar or intimidating and ask for unrealistic […]

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Dialogic Pedagogy in Equity, Diversity, and Inclusion (EDI) Learning

This project examines multidisciplinary methodologies in adult Equity, Diversity, and Inclusion (EDI) education, particularly focusing on strategies involving dialogic processes. Dialogic modes in learning broadly refer to activities of collaborative meaning-making through shared expression and communication rather than monologic processes, whereby fixed meaning is transferred through a one-way approach. As the demand for more conscientious […]

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Dialogic Pedagogy in Equity, Diversity, and Inclusion (EDI) Learning – Year Two

This project examines multidisciplinary methodologies in adult Equity, Diversity, and Inclusion (EDI) education, particularly focusing on strategies involving dialogic processes. Dialogic modes in learning broadly refer to activities of collaborative meaning-making through shared expression and communication rather than monologic processes, whereby fixed meaning is transferred through a one-way approach. As the demand for more conscientious […]

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Bioenergetics and population dynamics of polar bears past, present, and future: Understanding the effects of climate change – Year Two

In the Arctic, climate change is leading to declines in seasonal sea-ice cover. Polar bears are increasingly at-risk from sea-ice loss because they use the ice as a platform to hunt seals, their preferred food source. When the ice retreats seasonally, bears rely on their stored energy reserves as fuel, but climate-driven changes in sea-ice […]

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