Protein turnover is an incompletely understood aspect of biology, important for various processes including adaption to environmental stimuli. Over 500 protein complexes (E3 ligases) are involved in marking proteins for degradation, but only a small number of these E3 ligases are well characterised. The current project seeks to develop chemical inhibitors of GID4—a key component […]

The first successful clinical application of nanotechnology was the use of a nanoparticle container to deliver a drug to a tumour. That basic strategy of using a nanoparticle to carry a treatment or indicator molecule has a lot of potential, but requires continued research to determine the therapeutic effectiveness and potential toxicity of each container […]

This project is an undertaking in coordination with Minerva Canada, some of its industry partners and eight Canadian universities which aims to address a gap between industry and the graduates of engineering programs in terms of attitudes, knowledge and applied skills pertaining to health & safety in engineering practice. Upon completion, the project’s end product […]

Corticotropin-releasing factor (CRF) is a chemical found naturally in the brain that plays a key role in the mammalian stress response. CRF is also known to be involved in anxiety and mood disorders, as well as in various aspects of drug dependence, including long-term relapse to drug use. The teneurin C-terminal associated peptides (TCAP) comprise […]

Emerging therapeutic agents that function through the brain’s neurotransmitter systems have recently shown robust benefits in a number of otherwise challenging to treat neurological conditions including depression and post-traumatic stress disorder. The long-term changes that these agents induce within neural tissue is still however unclear. This MITSCS program aims to to use expertise in tissue […]

Groundswell, a Toronto-based design consultancy, is seeking to understand, study and experiment with new non-hierarchical organization structures. In partnership with UofT’s Business Design Initiative research team, they will investigate and experiment with the redesign of for-purpose and value-driven organizations to better respond to today’s economic climate described as volatile, uncertain, complex and ambiguous or VUCA. […]

Metal additive manufacturing (AM), also known as 3D Printing, is a technology that produces three-dimensional metallic parts layer by layer as opposed to conventional subtractive techniques. The qualities of 3D parts are significantly influenced by the characteristics of the feedstock materials, which depend on the manufacturing processes and also vary between batches. Powder pack density […]

The Structural Genomics Consortium (SGC) is a not-for-profit public-private partnership research organization that aims to accelerate the discovery of new medicines through open science. This Mitacs cluster will bring together SGC’s industry and academic collaborators to work together towards new and affordable medicines for challenging diseases. Sixty-three post-doctoral fellows will spend 2-3 years developing open […]

The Structural Genomics Consortium (SGC) is a not-for-profit public-private partnership research organization that aims to accelerate the discovery of new medicines through open science. This Mitacs cluster will bring together SGC’s industry and academic collaborators to work together towards new and affordable medicines for challenging diseases. Sixty-three post-doctoral fellows will spend 2-3 years developing open […]

Monitoring of wildland fires through infra-red remote sensing has become increasing of interest to the wildland fire management community, and quality scientific analysis of the capabilities of such sensors is critical if they are to be used in any operational way. In 2019 a joint burning experiment was carried out over several days. In 2019 […]

Radiologists use x-ray images of the human thoracic cavity to diagnose many diseases. One of the most common diagnoses, an enlarged heart, is detected by measure the cardiothoracic ratio – the ratio of the heart diameter to that of the thoracic cavity. Radiologists measure the cardiothoracic ratio (CTR) manually. This process is time-consuming and error-prone. […]

The proposed project seeks to develop biocomposite technology and products for the auto manufacturing industries. Eight graduate students under the supervision of Dr. Mohini Sain, will work on manufacturing processes, mechanical characterization and development of molds for various types of bio-composites which have direct application in auto-industries and can act as substitute for fossil fuel […]