The effectiveness of cancer drugs depends on several factors which are governed by the genetic and ‘epigenetic’ code of cancer cells. The epigenetic code comprises those heritable modifications that bookmark DNA and DNA-associated proteins to guide the expression of genetic attributes without changing the DNA sequence. This epigenetic code is written, read, and erased by […]

The effectiveness of cancer drugs depends on several factors which are governed by the genetic and ‘epigenetic’ code of cancer cells. The epigenetic code comprises those heritable modifications that bookmark DNA and DNA-associated proteins to guide the expression of genetic attributes without changing the DNA sequence. This epigenetic code is written, read, and erased by […]

This proposal aims to establish a collaborative research project between the City of Oshawa and the University of Toronto. It is part of the Teaching City Initiative. The immediate objective of this proposal is to use data collected over the last seven years to update pavement deterioration curves. The new dataset is larger (11700 data […]

Protein turnover is an incompletely understood aspect of biology, important for various processes including adaption to environmental stimuli. Over 500 protein complexes (E3 ligases) are involved in marking proteins for degradation, but only a small number of these E3 ligases are well characterised. The current project seeks to develop chemical inhibitors of GID4—a key component […]

Deep neural network (DNN) is a class of machine learning algorithms which is inspired by biological neural networks. Learning with deep neural networks has enjoyed huge empirical success in recent years across a wide variety of tasks. Lately many researchers in machine learning society have become interested in the generalization mystery: why do overparameterized DNN […]

Across the province, students are channeled into academic and applied programs at the start of high school. Students in applied courses are less likely to enjoy school or pass the provincial standards for achievement in both elementary and secondary school (EQAO, 2012). We know little about “who” takes applied courses in Ontario and what opportunities […]

Protein turnover is an incompletely understood aspect of biology, important for various processes including adaption to environmental stimuli. Over 500 protein complexes (E3 ligases) are involved in marking proteins for degradation, but only a small number of these E3 ligases are well characterised. The current project seeks to develop chemical inhibitors of GID4—a key component […]

The first successful clinical application of nanotechnology was the use of a nanoparticle container to deliver a drug to a tumour. That basic strategy of using a nanoparticle to carry a treatment or indicator molecule has a lot of potential, but requires continued research to determine the therapeutic effectiveness and potential toxicity of each container […]

This project is an undertaking in coordination with Minerva Canada, some of its industry partners and eight Canadian universities which aims to address a gap between industry and the graduates of engineering programs in terms of attitudes, knowledge and applied skills pertaining to health & safety in engineering practice. Upon completion, the project’s end product […]

Corticotropin-releasing factor (CRF) is a chemical found naturally in the brain that plays a key role in the mammalian stress response. CRF is also known to be involved in anxiety and mood disorders, as well as in various aspects of drug dependence, including long-term relapse to drug use. The teneurin C-terminal associated peptides (TCAP) comprise […]

Emerging therapeutic agents that function through the brain’s neurotransmitter systems have recently shown robust benefits in a number of otherwise challenging to treat neurological conditions including depression and post-traumatic stress disorder. The long-term changes that these agents induce within neural tissue is still however unclear. This MITSCS program aims to to use expertise in tissue […]

Groundswell, a Toronto-based design consultancy, is seeking to understand, study and experiment with new non-hierarchical organization structures. In partnership with UofT’s Business Design Initiative research team, they will investigate and experiment with the redesign of for-purpose and value-driven organizations to better respond to today’s economic climate described as volatile, uncertain, complex and ambiguous or VUCA. […]