Smart mutational exploration of the CalB lipase active site using a combination of virtual screening and iterative saturation mutagenesis

The company Odyssée Biotech specializes in the production of natural flavors and fragrances using innovative enzyme technologies. Using natural enzymes allows the enterprise to produce highly pure ingredients in mild conditions with a natural label. This green approach also makes this technology highly competitive and environmentally sustainable relative to other production methodologies employed in the […]

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Développement de nouveaux actifs et de nouvelles formules pour le secteur du cosmétique

Avec un marché qui devrait dépasser les 200 milliards de $ US en 2020, le domaine des produits cosmétiques et un moteur économique important à l’échelle mondiale, mais également canadien. Cette activité requiert de la part des entreprises un investissement important en recherche et développement afin de rester compétitive face à la concurrence. Cette proposition […]

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Building Capacity in Health Care Providers to Effectively CommunicateHealth Risk Information related to HIV with Clients and Patients. Phase 1.

The aim of The Ontario HIV Treatment Network (OHTN) is to help combat the spread of HIV by supporting, conducting, and sharing the best research possible. This project will involve a novel analysis incorporating focus groups with front-line service providers and key informants to help determine the factors that most influence the perception of HIV […]

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Development of new approaches to promote proliferation of insulin producing pancreatic ?-cells in diabetic patients

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]

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Development of a diagnostic assay for first line detection and surveillance of bladder urothelial carcinoma using concurrent biomarker panels from non-invasive liquid biopsies

Bladder Carcinoma (BC) is the fifth most common cancer in Canada. Although most individuals have surgery to remove BC tumors, the risk of another BC developing and/or progressing to invasive disease is high so long-term surveillance is necessary. The current method for screening for BC is not sensitive enough, and individuals often end up undergoing […]

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Production Line Packaging Sensor Validation and Optimization

This research project brings together current academia and a vibrant, growing commercial enterprise to solve real world problems. The industry partner has recently developed a high-tech, sensor-based diagnostic tool which will be evaluated by the graduate student intern. The capabilities and features of the tool will be extended through the innovative, collaborative design efforts of […]

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Network Traffic Profiling for generating intrusion detection evaluation datasets

Intrusion detection has attracted the attention of many researchers in identifying the ever-increasing issue of intrusive activities. In particular, anomaly detection has been the main focus of many researchers due to its potential in detecting novel attacks. However, its adoption to real-world applications has been hampered due to system complexity as these systems require a […]

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Measuring Knowledge Translation in Academic / Industry Collaborations

As manufacturing and resource-based industries face growing challenges, Canada’s future increasingly depends on advances in and sustainability of knowledge organizations. Knowledge-based workers comprise a growing proportion of the workforce today. More often than not, they work in the context of large-scale expert networks, spanning across different disciplines and organizations. They rely on software technologies for […]

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Deciphering the role of the tumor suppressor p53 in regulating treatment-induced ovarian cancer cell fate decisions in vivo

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that […]

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Adapting methods for assessing the impacts of innovation support programs for application to Canada’s clean energy innovation ecosystem

This research project is being undertaken in partnership with The Evidence Network Inc. It will extend the company’s scientifically-based method of assessing the impact of innovation support programs to the clean energy innovation sector. To keep this kind of assessment method scientifically sound requires customization for each particular industry. The established methods have been widely […]

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CYPRESS Video Analytic Framework

High definition acquisition devices have been commonly used in video capture. Millions of videos are recorded and stored daily. Due to the rapidly growing volume, effectively searching and matching the desired video clips from archives has become increasingly challenging. It may need days and weeks to locate the target information, such as suspected criminals, traffic […]

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