Investigating Cannflavins A and B as Inhibitors of TrkB Signaling for Treatment of Glioblastoma Multiforme

Glioblastoma is the most common type of adult brain cancer. Glioblastoma tumors are very aggressive because these cells can rapidly invade deep into healthy tissue, which makes them particularly difficult to attack with current treatment options including surgery, radiotherapy, and chemotherapy. Therefore, better pharmaceutical strategies to neutralize glioblastoma cells without damaging surrounding healthy cells is […]

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Critical minerals in the Antigonish Highlands, Nova Scotia

Natural Resources Canada (NRCan) recently developed a list of critical minerals that includes 31 minerals (chemical elements) deemed critical for Canada’s transition to greener energy. Critical elements are commodities that are geopolitically controlled, in low supply, or difficult to separate from other elements. Secure supplies of critical elements are essential for renewable energy and clean […]

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Deep Reinforcement Learning in the Search for New Antibacterials

Discovery and development of new antibiotics is becoming increasingly challenging, and in fact declining in the private sector because antibiotic-resistant bacterial infections are constantly evolving. One way to increase the antibiotic discovery rate is by taking advantage of the strides in Artificial Intelligence (AI)-based deep learning models to find new antibiotics that kill bacteria, as […]

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Data-driven food recommendations for reducing physiological dysregulation

Personalized nutrition and dietary recommendation products claiming to improve health are moving faster than the underlying science. Existing tools for communicating healthy foods are available, but they are designed for public (not individual) health, can not incorporate diet history, and can not adapt to the user’s preferred health outcomes. We propose to implement and fine-tune […]

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OLabERATE: OLab Education Research Analytics Toolset Expansion

Virtual scenarios, which are similar to choose-your-own-adventure stories, in online format, are a powerful way to assess how well a young professional can make decisions and solve problems. This is different from most learning software that tests how well they remember factoids and tidbits. OLab is a tool for playing and creating virtual scenarios. It […]

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THYKIOM : Thykamine anti-inflammatory and antioxidant mechanisms

The inflammation triggered by oxidative stress is the cause of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinical trial results have been mixed. A greater understanding of the mechanisms through which antioxidants act and where and when […]

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Utilizing Canadian digital technology to prevent and manage diabetes, obesity, and heart disease in patients living with Chronic Obstructive Pulmonary Disease (COPD) – A pilot study

50% of patients with Chronic Obstructive Pulmonary Disease (COPD) are at risk for having Metabolic Syndrome (Mets). While COPD is incurable, MetS can be reduced by diet and exercise. Yet, the evidence shows that lifestyle interventions with the self-management of health at home are low. Thus, The CHANGE program and My Viva Plan® (MVP) were […]

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Studying the biodegradability of eco-friendly straws in prospective disposal environments

The existing use of plastics is overwhelming, but unfortunately, non-biodegradable plastic is majorly used, which results in waste accumulation and danger to marine life. Efforts are being made to produce biodegradable plastic products, such that it degrades substantially after disposal and does not hurt our environment. However, there are many biodegradable plastics, with variable biodegradation […]

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Approche innovante pour les grands utilisateurs de service d’écoute téléphonique

Cette étude vise à dresser le portrait sociodémographique et de santé des appelants qui entrent en contact de façon récurrente avec les Centres d’écoute téléphonique et les stratégies et interventions employées par ces centres pour limiter la fréquence de cette utilisation. Dans le cadre de cette étude quatre catégories de répondants donneront leur point de […]

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Advancing a novel therapeutic for the prevention of hypoglycemia in rodent models of type 2 diabetes (T2DM) and in phase 1 and 2 human clinical trials for type 1 diabetes

Hypoglycemia or low blood sugar is a phenomenon that results from excess insulin or strenuous exercise in diabetic patients. If untreated, this can quickly lead to dizziness, seizures and even death. In healthy individuals, the body is able to compensate for these fluctuations and restore blood sugars to normal levels by lowering insulin and raising […]

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