Validation and Development of Clinically Relevant Copper Complexes for the Treatment of Bacterial Infections

Nearly 70% of all drug candidates are not pursued for pharmaceutical development because they cannot be dissolved into solutions appropriate for human use. Cuprous Pharmaceuticals Inc. (CPI) recently discovered that some of these drugs could be dissolved in the presence of certain metal ions. Furthermore, a number of metal-drug complexes are more therapeutically active than […]

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Effects of dietary glutathione precursors on cellular redox and mitochondrial efficiency in adults consuming a defined hypocaloric diet (Optifast-900; Nestlé Canada)

The aim of the proposed research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox normally occurs with aging and metabolic disorders, however, this study will focus on a […]

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Effects of dietary glutathione precursors on cellular redox and mitochondrial efficiency in adults consuming a defined hypocaloric diet (Optifast-900; Nestlé Canada) – Year two

The aim of this research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox is evident in obesity and metabolic disorders; Therefore, this study focuses on a population in […]

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Development of Li-Ion cells/batteries for low temperature applications

Increases in gasoline price and greenhouse gas emissions have spurred the growth of hybrid electric vehicles (HEV) and pure electric vehicles (EVs). Rechargeable Li-ion batteries are the leading candidate for powering these vehicles due to their high energy and power density properties relative to other batteries. However, their energy and power capabilities are substantially reduced […]

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Development of Li-Ion cells/batteries for low temperature applications – Year two

Rechargeable lithium-ion batteries are the leading candidate for powering hybrid electric vehicles (HEVs) and pure electric vehicles (EVs) due to their high energy density properties compared to other battery technologies. However, their performance is substantially reduced at temperatures below 0 °C, posing a technical barrier for market penetration of HEVs and EVs. The root cause […]

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Atomic Layer Deposition Tool – Testing and Process Development

Currently, no Canadian-based companies are involved in the manufacturing of state-of-the-art research tools for atomic layer deposition (ALD). Angstrom Engineering is a leading manufacturer of similar technologies – physical vapour deposition and chemical vapour deposition – and have identified an opportunity to produce the first ALD research tool manufactured entirely in Canada. ALD is a […]

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Atomic Layer Deposition Tool – Testing and Process Development – Year two

Currently, no Canadian-based companies are involved in the manufacturing of state-of-the-art research tools for atomic layer deposition (ALD). Angstrom Engineering is a leading manufacturer of similar technologies – physical vapour deposition and chemical vapour deposition – and have identified an opportunity to produce the first ALD research tool manufactured entirely in Canada. ALD is a […]

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Junior hockey competence analytics

Analytics is about awareness of the states of knowledge of users. Users can become aware of their owns states of knowledge at different levels. Analytics measures such levels of each user, and engages them in taking initiatives to hop from one knowledge state to the next. The hops happen mostly gradually, depending on the capacity […]

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Junior hockey competence analytics – Year two

We are developing a wearable hardware sensor and analysis software. The sensor collects activity and performance data, which is then analyzed by software and used to present feedback that players and coaches can use to improve performance.

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High energy density lithium ion cells/batteries with excellent electrochemical performance and safety

Li-ion batteries (LIBs) are currently the most important power source for a wide variety of applications such as cell phones, laptops, computers and other portable electronics. They are also considered as very promising storage/power systems for future electric/hybrid-electric powered transportation. Although clever cell design and improvements in cell subcomponents can bear potential for volume and […]

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High energy density lithium ion cells/batteries with excellent electrochemical performance and safety – Year two

Li-ion batteries (LIBs) are currently the most important power source for a wide variety of applications such as cell phones, laptops, computers and other portable electronics. They are also considered as very promising storage/power systems for future electric/hybrid-electric powered transportation. Although clever cell design and improvements in cell subcomponents can bear potential for volume and […]

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