Deamination of cytosine (C) and 5-methylcytosine (5mC) lead to GC to AT point mutations, which represent the major fraction of spontaneous mutations in a variety of genomes. We propose that most GC to AT mutations arise from the initial oxidation of C and 5C by reactive oxygen species followed by deamination of the intrinsic exocyclic […]

Le projet Mitacs à l’Université de McMaster vise à renforcer la collaboration académique avec le Département Global Peace and Social Justice (DGPSJ), une équipe pluridisciplinaire et multiculturelle. Cette collaboration a pour objectif de promouvoir les échanges et les discussions avec le DGPSJ en vue de concevoir un dispositif d’enseignement des langues étrangères (anglais et français) […]

Un défi scientifique et technologique contemporain majeur, contribuant à une réponse appropriée à l’ODD N°7 de l’ONU, consiste à impulser un changement de paradigme en passant des batteries lithium-ion (électrolyte liquide/gélifié) à des batteries dites tout-solides (électrolyte (inorganique, polymère) solide) plus sûres et performantes. Au-delà des accélérateurs de développements technologiques que constituent les domaines du […]

Les enjeux de ce projet de recherche se situent dans les transitions du monde agricole, en lien avec le besoin de répondre à la biodiversité, en réponse à la préservation de la planète, au réchauffement climatique et aux changements de comportements alimentaires des consommateurs. Ces transitions transforment les pratiques des agriculteurs, notamment avec des effets […]

The project investigates the distinction between two main forms of human memory, namely episodic (the experiential contextualized memory for personal past episodes) and semantic (the abstract de-contextualised memory for facts) memory. In line with recent proposals in philosophy, it calls this widely accepted distinction into question and explores a one-system conception of memory. The original […]

One of our research axes concerns the large-scale mechanical characterization of coarse granular materials (CGM). The prime objective of this collaboration is to enhance the database and develop scaling laws for testing CGM on representative small-scaled samples. This effort requires multiscale characterization on a wide range of coarse materials with different lithologies and particle shapes. […]

Hot Jupiters are giant gaseous planets, which orbit their host stars in a few days to hours. Due to these tight orbits, they are expected to rotate synchronously, ie always present the same face to their star. As a consequence, models predict these worlds to present strong westward winds, redistributing the heat from their permanent […]

The proposed research project aims to understand to what extent Canadian neighbourhoods vary based on the accessibility of transportation and identify which socially disadvantaged groups of people are most impacted by limited access to transport. The interns will analyze a large dataset released by “Infrastructure Canada and Statistics Canada” which measures how easy it is […]

The research project aims to enhance the security and reliability of navigation systems by developing advanced techniques for estimating the vehicle’s position and orientation, even in the presence of sensor attacks. By investigating the impact of potential attacks on sensor data, the project seeks to develop algorithms that can accurately estimate the vehicle’s location and […]

Cerebral Cavernous Malformations (CCM) are brain vascular malformations which occur in one person out of 200. Their consequences are devastating as they provoke epilepsy, stroke and many neurological disorders. CCM develop only in low blood flow venules and not in arteries in which the high flow has a protective effect. Yet, why CCM lesions form […]

In this research project, our focus is on the development of novel, safer methods of birth control. Our investigation centers around a reproductive hormone known as AMH, which can help prevent pregnancy without the side effects of traditional methods. Building on our exciting progress in animals like cats and mice, our immediate objective is to […]

The objective of the project is to develop robust path coverage algorithms for applications arising in search and rescue in earthquake struck urban areas and fault detection in energy distribution networks. The salient feature of the algorithms that will be developed is that they take uncertainty about the model into account and provides worst case […]