ALS (amyotrophic lateral sclerosis) is an incurable neurodegenerative characterized by the dysfunction and then death of motor neurons due to misfolded proteins. While healthy cells are equipped with a defence mechanism against protein misfolding known as protein quality control, it is possible that some neurons in ALS lose this mechanism. It is unknown why TDP-43 […]

This project aims to prepare a self-assembling and disassembling material from silicon and gold nanoparticles. The lifetime of this material is determined by the network of chemical reactions that control the assembly and disassembly of its constituents. The relative rates of these reactions, in turn, depend on the concentration of a chemical fuel. Silicon nanoparticles, […]

This project will perfect current quantitative electrophysiology technique (qEEGt) based on multivariate spectral analysis of magnetic-electrophysiology recordings to provide sensitive biomarkers for its use in the Precision Brain Health, including diagnostic, prediction, and intervention. We will take advantage of the Bayesian statistics to produce novel solutions and solve the main unresolved problems of quantitative electroencephalography […]

The energetic cost of traversing the environment is a fundamental component of an animal’s energetic balance and subsequently, their body condition. Polar bears (Ursus maritimus) occupy dynamic sea ice habitats, which result in spatiotemporal variation in their energetic costs of movement. My objective is to evaluate the role of energetic balance in governing polar bear […]

Community Sport Organizations (CSOs) exist to provide opportunities for sport participation for youth and adults in many countries around the world. These nonprofit, voluntary organizations face many challenges in an increasingly complex environment due to their diverse stakeholders, scarce resources, volunteer turnover among other issues (Allison, 2001; Hoye & Cuskelly, 2007). Interorganizational partnerships have been […]

“Bohemian matrices and applications” is a new and growing field in computational mathematics invented at Western University. The name “Bohemian” is a mnemonic for “Bounded Height Matrix of Integers”, which means that the entries of these matrices are drawn from a small set of numbers, such as {-1, 0, 1}. The original motivation for starting […]

Bubbly flows are ubiquitous in many systems and also fascinating from a fundamental perspective. Injecting bubbles into a liquid is often used to enhance mixing which leads to improvement in heat and/or mass transfer characteristics of the flow. This finds many applications in chemical industry, energy sector, and even biomedical engineering. This internship provides an […]

Traditional chemical separations, such as water filtration for example, are often energy intensive and require large amounts heat to achieve success. In an age with a growing need for clean technology, there has been increased demand for membranes capable of achieving these separations, without the traditional downfalls. These so called super-membranes are capable of producing […]

The Suzuki-Miyaura (SM) coupling reaction is a widely studied reaction between organoboron compounds and organic halides. Over the last 30 years the reaction has been improved as new discoveries are made in relation to the reactant species. Its applications extend to pharmaceutical and natural product synthesis due to its versatility. Unfortunately, several of the mechanisms […]

After leaving the hospital, about 65% of older adults go back into the hospital because of mobility problems. Mobility problems are caused by many factors such as cognitive (e.g. dementia) psychological (e.g. depression), physical (e.g. medical conditions), environmental (e.g. bad roads), financial (e.g. low income), social (e.g. relatives/friends) and personal (e.g. age). Usually, these mobility […]

This project will examine Virginia Gildersleeve’s role in the creation of the United Nations Charter at the 1945 San Francisco Conference. Gildersleeve was one of nine female delegates sent overall to the conference (out of 160) and the only woman on the American delegation. She significantly shaped the UN Charter and the foundation of the […]

The anterior cruciate ligament (ACL), one of the major ligaments maintaining stability of the knee, is frequently injured. Afterwards, a surgical reconstruction using a tendon graft is typically used to restore stability and allow individuals to achieve improved levels of mobility. Reconstruction involves taking a portion of tendon from elsewhere in the body and guiding/securing […]